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Ctnnbl1 catenin, beta like 1 [ Mus musculus (house mouse) ]

Gene ID: 66642, updated on 9-May-2024

Summary

Official Symbol
Ctnnbl1provided by MGI
Official Full Name
catenin, beta like 1provided by MGI
Primary source
MGI:MGI:1913892
See related
Ensembl:ENSMUSG00000027649 AllianceGenome:MGI:1913892
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NAP; P14L; NYD-SP19; 5730471K09Rik
Summary
Predicted to enable enzyme binding activity. Predicted to be involved in positive regulation of apoptotic process and somatic diversification of immunoglobulins. Predicted to act upstream of or within apoptotic process. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be part of Prp19 complex and spliceosomal complex. Is expressed in cerebral cortex ventricular layer; embryo; limb; and limb mesenchyme. Human ortholog(s) of this gene implicated in colorectal cancer and morbid obesity. Orthologous to human CTNNBL1 (catenin beta like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 25.7), CNS E11.5 (RPKM 19.2) and 28 other tissues See more
Orthologs
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Genomic context

See Ctnnbl1 in Genome Data Viewer
Location:
2 H1; 2 78.4 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157579321..157733823)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (157737401..157891903)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 25407 Neighboring gene STARR-positive B cell enhancer ABC_E2055 Neighboring gene predicted gene, 23463 Neighboring gene STARR-seq mESC enhancer starr_06218 Neighboring gene STARR-seq mESC enhancer starr_06220 Neighboring gene STARR-seq mESC enhancer starr_06222 Neighboring gene ubiquitin-conjugating enzyme E2I pseudogene Neighboring gene V-set and transmembrane domain containing 2-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ21108

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in somatic diversification of immunoglobulins ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Prp19 complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
beta-catenin-like protein 1
Names
nuclear protein NAP
nuclear-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025680.4NP_079956.3  beta-catenin-like protein 1

    See identical proteins and their annotated locations for NP_079956.3

    Status: VALIDATED

    Source sequence(s)
    AK145598, AL663092, AL669961
    Consensus CDS
    CCDS16982.1
    UniProtKB/Swiss-Prot
    Q3UL41, Q80X64, Q8VHE3, Q9CWL8
    UniProtKB/TrEMBL
    Q3UKS4
    Related
    ENSMUSP00000029178.7, ENSMUST00000029178.7
    Conserved Domains (2) summary
    cd00020
    Location:125227
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam08216
    Location:57159
    CTNNBL; Catenin-beta-like, Arm-motif containing nuclear

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    157579321..157733823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500022.3XP_006500085.1  beta-catenin-like protein 1 isoform X1