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Tsen15 tRNA splicing endonuclease subunit 15 [ Mus musculus (house mouse) ]

Gene ID: 66637, updated on 26-Sep-2022


Official Symbol
Tsen15provided by MGI
Official Full Name
tRNA splicing endonuclease subunit 15provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000014980 AllianceGenome:MGI:1913887
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sen15; 5730449L18Rik
Predicted to enable nuclease activity and nucleic acid binding activity. Predicted to be involved in tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to act upstream of or within mRNA processing and tRNA processing. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Orthologous to human TSEN15 (tRNA splicing endonuclease subunit 15). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in limb E14.5 (RPKM 14.7), placenta adult (RPKM 11.9) and 27 other tissues See more
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Genomic context

See Tsen15 in Genome Data Viewer
1; 1 G2
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (152246486..152262433, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (152370735..152386682, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53608 Neighboring gene predicted gene, 36920 Neighboring gene predicted gene, 41970 Neighboring gene basic transcription factor 3, pseudogene 14 Neighboring gene collagen beta(1-O)galactosyltransferase 2 Neighboring gene predicted gene, 51749 Neighboring gene ral guanine nucleotide dissociation stimulator,-like 1

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
involved_in tRNA splicing, via endonucleolytic cleavage and ligation IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
located_in nucleus IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
tRNA-splicing endonuclease subunit Sen15
tRNA splicing endonuclease 15 homolog
tRNA-intron endonuclease Sen15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025677.3NP_079953.2  tRNA-splicing endonuclease subunit Sen15

    See identical proteins and their annotated locations for NP_079953.2

    Status: VALIDATED

    Source sequence(s)
    AK017650, AW045476, BY065176
    Consensus CDS
    ENSMUSP00000015124.9, ENSMUST00000015124.15
    Conserved Domains (1) summary
    Sen15; Sen15 protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000067.7 Reference GRCm39 C57BL/6J

    152246486..152262433 complement
    GenBank, FASTA, Sequence Viewer (Graphics)