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Muc3 mucin 3, intestinal [ Mus musculus (house mouse) ]

Gene ID: 666339, updated on 26-Sep-2022

Summary

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Official Symbol
Muc3provided by MGI
Official Full Name
mucin 3, intestinalprovided by MGI
Primary source
MGI:MGI:1203527
See related
Ensembl:ENSMUSG00000037390 AllianceGenome:MGI:1203527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable PDZ domain binding activity. Located in apical plasma membrane and microvillus. Is expressed in bladder; testis; and ureter. Orthologous to human MUC17 (mucin 17, cell surface associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 3121.3), small intestine adult (RPKM 1038.7) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Muc3 in Genome Data Viewer
Location:
5 G2; 5 76.22 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137163772..137202809, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137134924..137166048, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade E, member 1 Neighboring gene tripartite motif-containing 56 Neighboring gene predicted gene, 40348 Neighboring gene predicted gene, 31160 Neighboring gene peptidyl-prolyl cis-trans isomerase G-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic modulation of adenosine receptor function and adenosine handling in murine hearts: insights and issues. Ashton KJ, et al. J Mol Cell Cardiol, 2007 Apr. PMID 17258765
  2. Characterization of the mouse Muc3 membrane bound intestinal mucin 5' coding and promoter regions: regulation by inflammatory cytokines. Shekels LL, et al. Biochim Biophys Acta, 2003 Jun 19. PMID 12818427
  3. Study of mucin turnover in the small intestine by in vivo labeling. Schneider H, et al. Sci Rep, 2018 Apr 10. PMID 29636525, Free PMC Article
  4. T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface. Cao E, et al. Immunity, 2007 Mar. PMID 17363302
  5. C-terminal domain of rodent intestinal mucin Muc3 is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components. Wang R, et al. Biochem J, 2002 Sep 1. PMID 12027806, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Muc17 (= Muc3) showed stable expression over time at the plasma membrane on villi tips, in crypts and at crypt openings. (In humans: Muc3 = Muc17)
    Title: Study of mucin turnover in the small intestine by in vivo labeling.
  2. Butyrate enemas upregulate Muc3 gene expression but decrease adherent mucus thickness in mice colon.
    Title: Butyrate enemas upregulate Muc genes expression but decrease adherent mucus thickness in mice colon.
  3. the expression of mucins 1 to 4 and trefoil factor 3 was down-regulated in the ileum and colon of conventional and reconventionalized mice compared with germ-free animals
    Title: Multifaceted transcriptional regulation of the murine intestinal mucus layer by endogenous microbiota.
  4. C-terminal domain is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components
    Title: C-terminal domain of rodent intestinal mucin Muc3 is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components.
  5. These data indicate that cytokines and growth factors are capable of regulating Muc3 gene expression, suggesting that this protein may play an active role in intestinal mucosal defense.
    Title: Characterization of the mouse Muc3 membrane bound intestinal mucin 5' coding and promoter regions: regulation by inflammatory cytokines.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular homeostasis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mucin 3, intestinal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010843.2 → NP_034973.2  mucin 3, intestinal precursor

    Status: VALIDATED

    Source sequence(s)
    AC242397, MG954266
    UniProtKB/TrEMBL
    E9PWP7
    Related
    ENSMUSP00000045196.11, ENSMUST00000041226.11
    Conserved Domains (1) summary
    smart00200
    Location:4185 → 4296
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137163772..137202809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165418.1 → XP_036021311.1  mucin 3, intestinal isoform X7

    Conserved Domains (1) summary
    smart00200
    Location:3717 → 3828
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

  2. XM_036165414.1 → XP_036021307.1  mucin 3, intestinal isoform X3

    Conserved Domains (1) summary
    smart00200
    Location:3765 → 3876
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

  3. XM_036165421.1 → XP_036021314.1  mucin 3, intestinal isoform X10

    Conserved Domains (1) summary
    smart00200
    Location:3693 → 3804
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

  4. XM_036165416.1 → XP_036021309.1  mucin 3, intestinal isoform X5

    Conserved Domains (1) summary
    smart00200
    Location:3741 → 3852
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

  5. XM_036165422.1 → XP_036021315.1  mucin 3, intestinal isoform X11

    Conserved Domains (1) summary
    smart00200
    Location:3681 → 3792
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

  6. XM_036165415.1 → XP_036021308.1  mucin 3, intestinal isoform X4

    Conserved Domains (1) summary
    smart00200
    Location:3759 → 3870
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

  7. XM_036165420.1 → XP_036021313.1  mucin 3, intestinal isoform X9

    Conserved Domains (1) summary
    smart00200
    Location:3711 → 3822
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

  8. XM_036165424.1 → XP_036021317.1  mucin 3, intestinal isoform X13

    Conserved Domains (1) summary
    smart00200
    Location:3392 → 3503
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

  9. XM_036165425.1 → XP_036021318.1  mucin 3, intestinal isoform X14

    Conserved Domains (1) summary
    smart00200
    Location:3356 → 3467
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

  10. XM_036165417.1 → XP_036021310.1  mucin 3, intestinal isoform X6

    Conserved Domains (1) summary
    smart00200
    Location:3741 → 3852
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

  11. XM_036165412.1 → XP_036021305.1  mucin 3, intestinal isoform X1

    Conserved Domains (1) summary
    smart00200
    Location:3789 → 3900
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

  12. XM_036165423.1 → XP_036021316.1  mucin 3, intestinal isoform X12

    Conserved Domains (1) summary
    smart00200
    Location:3579 → 3690
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

  13. XM_036165413.1 → XP_036021306.1  mucin 3, intestinal isoform X2

    Conserved Domains (1) summary
    smart00200
    Location:3789 → 3900
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

  14. XM_036165427.1 → XP_036021320.1  mucin 3, intestinal isoform X16

    Conserved Domains (1) summary
    smart00200
    Location:2288 → 2399
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

  15. XM_036165426.1 → XP_036021319.1  mucin 3, intestinal isoform X15

    Conserved Domains (1) summary
    smart00200
    Location:3236 → 3347
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

  16. XM_036165419.1 → XP_036021312.1  mucin 3, intestinal isoform X8

    Conserved Domains (1) summary
    smart00200
    Location:3711 → 3822
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
Nucleotide Protein Strain
Heading Accession and Version

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