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SOX5 SRY-box transcription factor 5 [ Homo sapiens (human) ]

Gene ID: 6660, updated on 11-Sep-2019

Summary

Official Symbol
SOX5provided by HGNC
Official Full Name
SRY-box transcription factor 5provided by HGNC
Primary source
HGNC:HGNC:11201
See related
Ensembl:ENSG00000134532 MIM:604975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L-SOX5; LAMSHF; L-SOX5B; L-SOX5F
Summary
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 2.2), brain (RPKM 1.6) and 22 other tissues See more
Orthologs

Genomic context

See SOX5 in Genome Data Viewer
Location:
12p12.1
Exon count:
29
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (23529499..24562701, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (23682438..24715383, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1603 Neighboring gene uncharacterized LOC101928441 Neighboring gene uncharacterized LOC105369697 Neighboring gene uncharacterized LOC105369696 Neighboring gene VISTA enhancer hs895 Neighboring gene Sharpr-MPRA regulatory region 6359 Neighboring gene SOX5 antisense RNA 1 Neighboring gene microRNA 920 Neighboring gene uncharacterized LOC105369698 Neighboring gene long intergenic non-protein coding RNA 477 Neighboring gene lysine rich nucleolar protein 1 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 102

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Lamb-shaffer syndrome
MedGen: C4225202 OMIM: 616803 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2016-08-19)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2016-08-19)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
NHGRI GWA Catalog
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
NHGRI GWA Catalog
Genome-wide association of lipid-lowering response to statins in combined study populations.
NHGRI GWA Catalog
Genome-wide association study of PR interval.
NHGRI GWA Catalog
Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).
NHGRI GWA Catalog
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
NHGRI GWA Catalog
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
NHGRI GWA Catalog

Pathways from BioSystems

  • Endochondral Ossification, organism-specific biosystem (from WikiPathways)
    Endochondral Ossification, organism-specific biosystemEndochondral ossification is the process by which the embryonic cartilaginous model of most bones contributes to longitudinal growth and is gradually replaced by bone. During endochondral ossificatio...
  • Neural Crest Differentiation, organism-specific biosystem (from WikiPathways)
    Neural Crest Differentiation, organism-specific biosystemGene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involv...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC35153

Gene Ontology Provided by GOA

Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transcription factor SOX-5
Names
SRY (sex determining region Y)-box 5
SRY-box 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029612.2 RefSeqGene

    Range
    4956..1037943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001261414.3NP_001248343.1  transcription factor SOX-5 isoform d

    See identical proteins and their annotated locations for NP_001248343.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame segment compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AB081589, AC087244, BC060773, BM988193, BX098902, DA343699
    Consensus CDS
    CCDS58216.1
    UniProtKB/Swiss-Prot
    P35711
    Related
    ENSP00000493866.1, ENST00000646273.1
    Conserved Domains (1) summary
    cd01388
    Location:434505
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  2. NM_001261415.2NP_001248344.1  transcription factor SOX-5 isoform e

    See identical proteins and their annotated locations for NP_001248344.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate first exon compared to variant 1. The resulting isoform (e) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AB081589, AC087244, AK303970, BM988193, BX098902
    Consensus CDS
    CCDS58217.1
    UniProtKB/Swiss-Prot
    P35711
    Related
    ENSP00000443520.1, ENST00000545921.5
    Conserved Domains (1) summary
    cd01388
    Location:545616
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  3. NM_001330785.2NP_001317714.1  transcription factor SOX-5 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (f) is shorter but has the same N- and C-termini compared to isoform a.
    Source sequence(s)
    AB081588, AC087244, BM988193, BX098902, DR003434
    Consensus CDS
    CCDS81672.1
    UniProtKB/Swiss-Prot
    P35711
    UniProtKB/TrEMBL
    F5H0I3
    Related
    ENSP00000439832.1, ENST00000537393.5
    Conserved Domains (1) summary
    cd01388
    Location:520591
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  4. NM_006940.6NP_008871.3  transcription factor SOX-5 isoform a

    See identical proteins and their annotated locations for NP_008871.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a, also called L-SOX5A).
    Source sequence(s)
    AB081589, AC087244, BM988193, BX098902
    Consensus CDS
    CCDS8699.1
    UniProtKB/Swiss-Prot
    P35711
    UniProtKB/TrEMBL
    A0A024RB06
    Related
    ENSP00000398273.2, ENST00000451604.7
    Conserved Domains (1) summary
    cd01388
    Location:555626
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  5. NM_152989.5NP_694534.1  transcription factor SOX-5 isoform b

    See identical proteins and their annotated locations for NP_694534.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b, also called L-SOX5B) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AB081588, AC087244, BC060773, BM988193, BX098902, DA343699
    Consensus CDS
    CCDS44844.1
    UniProtKB/Swiss-Prot
    P35711
    UniProtKB/TrEMBL
    T2CYZ2
    Related
    ENSP00000441973.2, ENST00000541536.6
    Conserved Domains (1) summary
    cd01388
    Location:542613
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  6. NM_178010.4NP_821078.1  transcription factor SOX-5 isoform c

    See identical proteins and their annotated locations for NP_821078.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate first exon in place of much of the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AB081589, AC087244, AK098610, BM988193, BX098902
    Consensus CDS
    CCDS41761.1
    UniProtKB/Swiss-Prot
    P35711
    Related
    ENSP00000379328.2, ENST00000396007.6
    Conserved Domains (1) summary
    cd01388
    Location:169240
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    23529499..24562701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449159.1XP_024304927.1  transcription factor SOX-5 isoform X5

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  2. XM_024449158.1XP_024304926.1  transcription factor SOX-5 isoform X5

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  3. XM_024449165.1XP_024304933.1  transcription factor SOX-5 isoform X8

    Conserved Domains (1) summary
    cd01388
    Location:508579
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  4. XM_024449157.1XP_024304925.1  transcription factor SOX-5 isoform X5

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  5. XM_017019893.1XP_016875382.1  transcription factor SOX-5 isoform X5

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  6. XM_024449154.1XP_024304922.1  transcription factor SOX-5 isoform X5

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  7. XM_024449152.1XP_024304920.1  transcription factor SOX-5 isoform X5

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  8. XM_011520835.2XP_011519137.1  transcription factor SOX-5 isoform X5

    See identical proteins and their annotated locations for XP_011519137.1

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  9. XM_024449153.1XP_024304921.1  transcription factor SOX-5 isoform X5

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  10. XM_024449150.1XP_024304918.1  transcription factor SOX-5 isoform X5

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  11. XM_024449161.1XP_024304929.1  transcription factor SOX-5 isoform X6

    Conserved Domains (1) summary
    cd01388
    Location:542613
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  12. XM_024449160.1XP_024304928.1  transcription factor SOX-5 isoform X6

    Conserved Domains (1) summary
    cd01388
    Location:542613
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  13. XM_011520834.2XP_011519136.1  transcription factor SOX-5 isoform X5

    See identical proteins and their annotated locations for XP_011519136.1

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  14. XM_017019898.1XP_016875387.1  transcription factor SOX-5 isoform X9

    UniProtKB/TrEMBL
    T2CZM2
    Conserved Domains (1) summary
    cd01388
    Location:507578
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  15. XM_017019897.1XP_016875386.1  transcription factor SOX-5 isoform X8

    Conserved Domains (1) summary
    cd01388
    Location:508579
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  16. XM_017019896.1XP_016875385.1  transcription factor SOX-5 isoform X6

    UniProtKB/Swiss-Prot
    P35711
    UniProtKB/TrEMBL
    T2CYZ2
    Conserved Domains (1) summary
    cd01388
    Location:542613
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  17. XM_017019890.1XP_016875379.1  transcription factor SOX-5 isoform X5

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  18. XM_017019892.1XP_016875381.1  transcription factor SOX-5 isoform X5

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  19. XM_024449163.1XP_024304931.1  transcription factor SOX-5 isoform X8

    Conserved Domains (1) summary
    cd01388
    Location:508579
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  20. XM_017019891.1XP_016875380.1  transcription factor SOX-5 isoform X5

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  21. XM_017019899.1XP_016875388.1  transcription factor SOX-5 isoform X9

    UniProtKB/TrEMBL
    T2CZM2
    Conserved Domains (1) summary
    cd01388
    Location:507578
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  22. XM_024449155.1XP_024304923.1  transcription factor SOX-5 isoform X5

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  23. XM_024449151.1XP_024304919.1  transcription factor SOX-5 isoform X5

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  24. XM_024449164.1XP_024304932.1  transcription factor SOX-5 isoform X8

    Conserved Domains (1) summary
    cd01388
    Location:508579
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  25. XM_017019894.1XP_016875383.1  transcription factor SOX-5 isoform X5

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  26. XM_011520833.2XP_011519135.1  transcription factor SOX-5 isoform X4

    See identical proteins and their annotated locations for XP_011519135.1

    Conserved Domains (1) summary
    cd01388
    Location:546617
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  27. XM_017019900.1XP_016875389.1  transcription factor SOX-5 isoform X9

    UniProtKB/TrEMBL
    T2CZM2
    Conserved Domains (1) summary
    cd01388
    Location:507578
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  28. XM_017019888.1XP_016875377.1  transcription factor SOX-5 isoform X1

  29. XM_017019889.1XP_016875378.1  transcription factor SOX-5 isoform X2

  30. XM_017019895.1XP_016875384.1  transcription factor SOX-5 isoform X5

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  31. XM_011520832.2XP_011519134.1  transcription factor SOX-5 isoform X3

    See identical proteins and their annotated locations for XP_011519134.1

    Conserved Domains (1) summary
    cd01388
    Location:556627
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  32. XM_011520838.2XP_011519140.1  transcription factor SOX-5 isoform X7

    See identical proteins and their annotated locations for XP_011519140.1

    Conserved Domains (1) summary
    cd01388
    Location:521592
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  33. XM_017019901.1XP_016875390.1  transcription factor SOX-5 isoform X9

    UniProtKB/TrEMBL
    T2CZM2
    Conserved Domains (1) summary
    cd01388
    Location:507578
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  34. XM_011520837.2XP_011519139.1  transcription factor SOX-5 isoform X5

    See identical proteins and their annotated locations for XP_011519139.1

    Conserved Domains (1) summary
    cd01388
    Location:543614
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  35. XM_011520842.2XP_011519144.1  transcription factor SOX-5 isoform X12

    Conserved Domains (1) summary
    cd01388
    Location:207278
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  36. XM_017019903.1XP_016875392.1  transcription factor SOX-5 isoform X11

  37. XM_017019902.1XP_016875391.1  transcription factor SOX-5 isoform X10

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