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Gtf3a general transcription factor III A [ Mus musculus (house mouse) ]

Gene ID: 66596, updated on 26-Sep-2022


Official Symbol
Gtf3aprovided by MGI
Official Full Name
general transcription factor III Aprovided by MGI
Primary source
See related
Ensembl:ENSMUSG00000016503 AllianceGenome:MGI:1913846
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010015D03Rik; 2610111I01Rik; 5330403M05Rik
The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]
Ubiquitous expression in ovary adult (RPKM 66.8), colon adult (RPKM 54.2) and 28 other tissues See more
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Genomic context

See Gtf3a in Genome Data Viewer
5; 5 G3
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (146885467..146892424)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (146948657..146955614)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38748 Neighboring gene predicted gene 10858 Neighboring gene mitochondrial translational initiation factor 3 Neighboring gene predicted gene, 46936 Neighboring gene ligand of numb-protein X 2

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information



Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5S rRNA binding ISO
Inferred from Sequence Orthology
more info
enables DNA binding IDA
Inferred from Direct Assay
more info
enables DNA binding ISO
Inferred from Sequence Orthology
more info
enables RNA binding IEA
Inferred from Electronic Annotation
more info
enables RNA polymerase III general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in ribosomal large subunit biogenesis ISO
Inferred from Sequence Orthology
more info
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info

General protein information

Preferred Names
transcription factor IIIA
factor A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025652.3NP_079928.2  transcription factor IIIA

    See identical proteins and their annotated locations for NP_079928.2

    Status: REVIEWED

    Source sequence(s)
    AC124828, AF391799, BE656279, BI202484
    Consensus CDS
    Q8VHT7, Q9CSH8
    ENSMUSP00000119607.2, ENSMUST00000146511.8
    Conserved Domains (2) summary
    COG5048; FOG: Zn-finger [General function prediction only]
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000071.7 Reference GRCm39 C57BL/6J

    GenBank, FASTA, Sequence Viewer (Graphics)