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Defa42 defensin, alpha, 42 [ Mus musculus (house mouse) ]

Gene ID: 665927, updated on 13-Oct-2022

Summary

Official Symbol
Defa42provided by MGI
Official Full Name
defensin, alpha, 42provided by MGI
Primary source
MGI:MGI:3645033
See related
Ensembl:ENSMUSG00000079114 AllianceGenome:MGI:3645033
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm7849; EG665927
Summary
Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; innate immune response in mucosa; and response to bacterium. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward large intestine adult (RPKM 1237.4) See more
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Genomic context

See Defa42 in Genome Data Viewer
Location:
8; 8 A2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (21945443..21946533, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (21455427..21456517, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene defensin, alpha, pseudogene 18 Neighboring gene ribosomal protein L21 pseudogene Neighboring gene predicted gene, 23568 Neighboring gene zinc finger, MYM-type 5 pseudogene Neighboring gene defensin, alpha, pseudogene 17

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response in mucosa IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in azurophil granule ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
alpha-defensin 42
Names
novel defensin-related cryptidin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177518.1NP_001170989.1  alpha-defensin 42 precursor

    See identical proteins and their annotated locations for NP_001170989.1

    Status: VALIDATED

    Source sequence(s)
    AC239604
    Consensus CDS
    CCDS52508.1
    UniProtKB/TrEMBL
    D3YX03
    Related
    ENSMUSP00000106380.4, ENSMUST00000110752.4
    Conserved Domains (1) summary
    pfam00879
    Location:2051
    Defensin_propep; Defensin propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    21945443..21946533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)