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Hmcn2 hemicentin 2 [ Mus musculus (house mouse) ]

Gene ID: 665700, updated on 13-Dec-2022

Summary

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Official Symbol
Hmcn2provided by MGI
Official Full Name
hemicentin 2provided by MGI
Primary source
MGI:MGI:2677838
See related
Ensembl:ENSMUSG00000055632 AllianceGenome:MGI:2677838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D030068H01
Summary
Predicted to enable calcium ion binding activity. Predicted to be an extracellular matrix structural constituent. Located in several cellular components, including basement membrane; cell cortex; and extracellular region. Is expressed in early embryo; gut; lung; and reproductive system. Orthologous to human HMCN2 (hemicentin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 30.0), duodenum adult (RPKM 18.2) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Hmcn2 in Genome Data Viewer
Location:
2; 2 B
Exon count:
99
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (31204273..31350751)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (31314255..31460738)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 107 Neighboring gene predicted gene, 22516 Neighboring gene neuronal calcium sensor 1 Neighboring gene argininosuccinate synthetase 1 Neighboring gene predicted gene, 32952 Neighboring gene predicted gene 13426

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mammalian hemicentin 1 is assembled into tracks in the extracellular matrix of multiple tissues. Lin MH, et al. Dev Dyn, 2020 Jun. PMID 32035013, Free PMC Article
  2. Vertebrate extracellular matrix protein hemicentin-1 interacts physically and genetically with basement membrane protein nidogen-2. Zhang JL, et al. Matrix Biol, 2022 Sep. PMID 36007682, Free PMC Article
  3. Hemicentin-1 is an essential extracellular matrix component of the dermal-epidermal and myotendinous junctions. Welcker D, et al. Sci Rep, 2021 Sep 9. PMID 34504132, Free PMC Article
  4. A secreted protein promotes cleavage furrow maturation during cytokinesis. Xu X, et al. Curr Biol, 2011 Jan 25. PMID 21215633, Free PMC Article
  5. Hemicentins assemble on diverse epithelia in the mouse. Xu X, et al. J Histochem Cytochem, 2007 Feb. PMID 17015624

See all (20) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC31312, MGC49669

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables axon guidance receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
hemicentin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370902.1 → NP_001357831.1  hemicentin-2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL732564, AL732572, AL928861
    Related
    ENSMUSP00000109160.3, ENSMUST00000113532.9
    Conserved Domains (12) summary
    smart00408
    Location:4242 → 4304
    IGc2; Immunoglobulin C-2 Type
    smart00179
    Location:4879 → 4918
    EGF_CA; Calcium-binding EGF-like domain
    smart00409
    Location:793 → 876
    IG; Immunoglobulin
    smart00410
    Location:707 → 783
    IG_like; Immunoglobulin like
    cd00198
    Location:38 → 196
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam07645
    Location:4684 → 4727
    EGF_CA; Calcium-binding EGF domain
    cd00096
    Location:3239 → 3303
    Ig; Immunoglobulin domain
    pfam07474
    Location:4406 → 4588
    G2F; G2F domain
    pfam07679
    Location:4318 → 4404
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:1981 → 2056
    Ig_3; Immunoglobulin domain
    pfam14670
    Location:4647 → 4682
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl11960
    Location:1262 → 1336
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    31204273..31350751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498503.5 → XP_006498566.1  hemicentin-2 isoform X2

    Conserved Domains (12) summary
    smart00408
    Location:4259 → 4321
    IGc2; Immunoglobulin C-2 Type
    smart00179
    Location:4789 → 4829
    EGF_CA; Calcium-binding EGF-like domain
    smart00409
    Location:1553 → 1633
    IG; Immunoglobulin
    smart00410
    Location:793 → 876
    IG_like; Immunoglobulin like
    cd00198
    Location:38 → 196
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam07645
    Location:4701 → 4744
    EGF_CA; Calcium-binding EGF domain
    cd00096
    Location:3256 → 3320
    Ig; Immunoglobulin domain
    pfam07474
    Location:4423 → 4605
    G2F; G2F domain
    pfam07679
    Location:4335 → 4421
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:1998 → 2073
    Ig_3; Immunoglobulin domain
    pfam14670
    Location:4664 → 4699
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl11960
    Location:1262 → 1336
    Ig; Immunoglobulin domain

  2. XM_006498501.5 → XP_006498564.1  hemicentin-2 isoform X1

    Conserved Domains (12) summary
    smart00408
    Location:4259 → 4321
    IGc2; Immunoglobulin C-2 Type
    smart00179
    Location:4896 → 4935
    EGF_CA; Calcium-binding EGF-like domain
    smart00409
    Location:707 → 783
    IG; Immunoglobulin
    smart00410
    Location:793 → 876
    IG_like; Immunoglobulin like
    cd00198
    Location:38 → 196
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam07645
    Location:4701 → 4744
    EGF_CA; Calcium-binding EGF domain
    cd00096
    Location:3256 → 3320
    Ig; Immunoglobulin domain
    pfam07474
    Location:4423 → 4605
    G2F; G2F domain
    pfam07679
    Location:4335 → 4421
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:1998 → 2073
    Ig_3; Immunoglobulin domain
    pfam14670
    Location:4664 → 4699
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl11960
    Location:1262 → 1336
    Ig; Immunoglobulin domain

  3. XM_006498504.2 → XP_006498567.1  hemicentin-2 isoform X3

    Conserved Domains (11) summary
    smart00408
    Location:4104 → 4166
    IGc2; Immunoglobulin C-2 Type
    smart00179
    Location:4741 → 4780
    EGF_CA; Calcium-binding EGF-like domain
    smart00409
    Location:638 → 721
    IG; Immunoglobulin
    smart00410
    Location:552 → 628
    IG_like; Immunoglobulin like
    pfam07645
    Location:4546 → 4589
    EGF_CA; Calcium-binding EGF domain
    cd00096
    Location:3101 → 3165
    Ig; Immunoglobulin domain
    pfam07474
    Location:4268 → 4450
    G2F; G2F domain
    pfam07679
    Location:4180 → 4266
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:1843 → 1918
    Ig_3; Immunoglobulin domain
    pfam14670
    Location:4509 → 4544
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl11960
    Location:1107 → 1181
    Ig; Immunoglobulin domain

RNA

  1. XR_003953689.2 RNA Sequence

    Related
    ENSMUST00000226996.2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177649.5: Suppressed sequence

    Description
    NM_177649.5: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AJ76.1 GenPept UniProtKB/Swiss-Prot:A2AJ76

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials