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Hmcn2 hemicentin 2 [ Mus musculus (house mouse) ]

Gene ID: 665700, updated on 27-Nov-2024

Summary

Official Symbol
Hmcn2provided by MGI
Official Full Name
hemicentin 2provided by MGI
Primary source
MGI:MGI:2677838
See related
Ensembl:ENSMUSG00000055632 AllianceGenome:MGI:2677838
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D030068H01
Summary
Predicted to enable axon guidance receptor activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules and synapse organization. Located in several cellular components, including basement membrane; cell cortex; and extracellular region. Is expressed in several structures, including early embryo; gut; hindlimb muscle; lung; and skin. Orthologous to human HMCN2 (hemicentin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in colon adult (RPKM 30.0), duodenum adult (RPKM 18.2) and 10 other tissues See more
Orthologs
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Genomic context

See Hmcn2 in Genome Data Viewer
Location:
2 B; 2 21.81 cM
Exon count:
99
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (31204273..31350751)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (31314255..31460738)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 107 Neighboring gene predicted gene, 22516 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:31112123-31112306 Neighboring gene neuronal calcium sensor 1 Neighboring gene STARR-seq mESC enhancer starr_04149 Neighboring gene STARR-positive B cell enhancer ABC_E504 Neighboring gene argininosuccinate synthetase 1 Neighboring gene predicted gene, 32952 Neighboring gene predicted gene 13426

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC31312, MGC49669

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables axon guidance receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Process Evidence Code Pubs
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370902.1NP_001357831.1  hemicentin-2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL732564, AL732572, AL928861
    UniProtKB/Swiss-Prot
    A2AJ76, Q8BNH3
    Related
    ENSMUSP00000109160.3, ENSMUST00000113532.9
    Conserved Domains (12) summary
    smart00408
    Location:42424304
    IGc2; Immunoglobulin C-2 Type
    smart00179
    Location:48794918
    EGF_CA; Calcium-binding EGF-like domain
    smart00409
    Location:793876
    IG; Immunoglobulin
    smart00410
    Location:707783
    IG_like; Immunoglobulin like
    cd00198
    Location:38196
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam07645
    Location:46844727
    EGF_CA; Calcium-binding EGF domain
    cd00096
    Location:32393303
    Ig; Immunoglobulin domain
    pfam07474
    Location:44064588
    G2F; G2F domain
    pfam07679
    Location:43184404
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:19812056
    Ig_3; Immunoglobulin domain
    pfam14670
    Location:46474682
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl11960
    Location:12621336
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    31204273..31350751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498503.5XP_006498566.1  hemicentin-2 isoform X2

    UniProtKB/Swiss-Prot
    A2AJ76, Q8BNH3
    Conserved Domains (12) summary
    smart00408
    Location:42594321
    IGc2; Immunoglobulin C-2 Type
    smart00179
    Location:47894829
    EGF_CA; Calcium-binding EGF-like domain
    smart00409
    Location:15531633
    IG; Immunoglobulin
    smart00410
    Location:793876
    IG_like; Immunoglobulin like
    cd00198
    Location:38196
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam07645
    Location:47014744
    EGF_CA; Calcium-binding EGF domain
    cd00096
    Location:32563320
    Ig; Immunoglobulin domain
    pfam07474
    Location:44234605
    G2F; G2F domain
    pfam07679
    Location:43354421
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:19982073
    Ig_3; Immunoglobulin domain
    pfam14670
    Location:46644699
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl11960
    Location:12621336
    Ig; Immunoglobulin domain
  2. XM_006498501.5XP_006498564.1  hemicentin-2 isoform X1

    UniProtKB/Swiss-Prot
    A2AJ76, Q8BNH3
    Conserved Domains (12) summary
    smart00408
    Location:42594321
    IGc2; Immunoglobulin C-2 Type
    smart00179
    Location:48964935
    EGF_CA; Calcium-binding EGF-like domain
    smart00409
    Location:707783
    IG; Immunoglobulin
    smart00410
    Location:793876
    IG_like; Immunoglobulin like
    cd00198
    Location:38196
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam07645
    Location:47014744
    EGF_CA; Calcium-binding EGF domain
    cd00096
    Location:32563320
    Ig; Immunoglobulin domain
    pfam07474
    Location:44234605
    G2F; G2F domain
    pfam07679
    Location:43354421
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:19982073
    Ig_3; Immunoglobulin domain
    pfam14670
    Location:46644699
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl11960
    Location:12621336
    Ig; Immunoglobulin domain
  3. XM_006498504.2XP_006498567.1  hemicentin-2 isoform X3

    UniProtKB/Swiss-Prot
    A2AJ76, Q8BNH3
    Conserved Domains (11) summary
    smart00408
    Location:41044166
    IGc2; Immunoglobulin C-2 Type
    smart00179
    Location:47414780
    EGF_CA; Calcium-binding EGF-like domain
    smart00409
    Location:638721
    IG; Immunoglobulin
    smart00410
    Location:552628
    IG_like; Immunoglobulin like
    pfam07645
    Location:45464589
    EGF_CA; Calcium-binding EGF domain
    cd00096
    Location:31013165
    Ig; Immunoglobulin domain
    pfam07474
    Location:42684450
    G2F; G2F domain
    pfam07679
    Location:41804266
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:18431918
    Ig_3; Immunoglobulin domain
    pfam14670
    Location:45094544
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl11960
    Location:11071181
    Ig; Immunoglobulin domain

RNA

  1. XR_003953689.2 RNA Sequence

    Related
    ENSMUST00000226996.2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177649.5: Suppressed sequence

    Description
    NM_177649.5: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.