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Cul7 cullin 7 [ Mus musculus (house mouse) ]

Gene ID: 66515, updated on 23-Mar-2024

Summary

Official Symbol
Cul7provided by MGI
Official Full Name
cullin 7provided by MGI
Primary source
MGI:MGI:1913765
See related
Ensembl:ENSMUSG00000038545 AllianceGenome:MGI:1913765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p185; p193; 2510004L20Rik; C230011P08Rik
Summary
Predicted to enable ubiquitin protein ligase binding activity. Involved in vasculogenesis. Part of Cul7-RING ubiquitin ligase complex. Is expressed in several structures, including Meckel's cartilage; extraembryonic component; placenta; and skeleton. Human ortholog(s) of this gene implicated in 3-M syndrome. Orthologous to human CUL7 (cullin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 31.4), placenta adult (RPKM 28.7) and 27 other tissues See more
Orthologs
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Genomic context

Location:
17 C; 17 22.9 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46961264..46975290)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46650338..46664364)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene PTK7 protein tyrosine kinase 7 Neighboring gene VISTA enhancer mm1620 Neighboring gene STARR-seq mESC enhancer starr_42674 Neighboring gene STARR-seq mESC enhancer starr_42675 Neighboring gene STARR-positive B cell enhancer ABC_E10957 Neighboring gene kinesin light chain 4 Neighboring gene STARR-positive B cell enhancer ABC_E7536 Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene STARR-seq mESC enhancer starr_42676 Neighboring gene ribosomal RNA processing 36 Neighboring gene STARR-positive B cell enhancer mm9_chr17:46817738-46818039 Neighboring gene kelch domain containing 3 Neighboring gene male enhanced antigen 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in placenta development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
involved_in regulation of endothelial cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of 3M complex ISO
Inferred from Sequence Orthology
more info
 
part_of Cul7-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Cul7-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of cullin-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025611.5NP_079887.3  cullin-7

    See identical proteins and their annotated locations for NP_079887.3

    Status: VALIDATED

    Source sequence(s)
    BC059865, BC065096, BY749504
    Consensus CDS
    CCDS28833.1
    UniProtKB/Swiss-Prot
    Q3UHY3, Q497I2, Q6A0D6, Q6PB63, Q8R3W4, Q8VE73, Q9CVD5
    UniProtKB/TrEMBL
    A9C491
    Related
    ENSMUSP00000049128.8, ENSMUST00000043464.14
    Conserved Domains (3) summary
    pfam11515
    Location:352423
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl02148
    Location:817947
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:15521630
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46961264..46975290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)