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Ndufb3 NADH:ubiquinone oxidoreductase subunit B3 [ Mus musculus (house mouse) ]

Gene ID: 66495, updated on 8-Dec-2022

Summary

Official Symbol
Ndufb3provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase subunit B3provided by MGI
Primary source
MGI:MGI:1913745
See related
Ensembl:ENSMUSG00000026032 AllianceGenome:MGI:1913745
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CI-B12; 2700033I16Rik
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 25. Orthologous to human NDUFB3 (NADH:ubiquinone oxidoreductase subunit B3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 65.8), bladder adult (RPKM 47.1) and 26 other tissues See more
Orthologs
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Genomic context

See Ndufb3 in Genome Data Viewer
Location:
1; 1 C1.3
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58625556..58635123)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58586397..58595964)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23966 Neighboring gene origin recognition complex, subunit 2 Neighboring gene predicted gene 15834 Neighboring gene hyccin PI4KA lipid kinase complex subunit 2 Neighboring gene Fanconi anemia, complementation group L pseudogene Neighboring gene chromobox 3, pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane HDA PubMed 
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
Names
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3
NADH-ubiquinone oxidoreductase B12 subunit
complex I-B12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025597.3NP_079873.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

    See identical proteins and their annotated locations for NP_079873.1

    Status: VALIDATED

    Source sequence(s)
    AC118698, BC028669, CK621544
    Consensus CDS
    CCDS14977.1
    UniProtKB/Swiss-Prot
    Q3UUR9, Q9CQZ6
    UniProtKB/TrEMBL
    A0A8C6N1G2
    Related
    ENSMUSP00000027193.9, ENSMUST00000027193.9
    Conserved Domains (1) summary
    pfam08122
    Location:48103
    NDUF_B12; NADH-ubiquinone oxidoreductase B12 subunit family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58625556..58635123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)