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Exoc2 exocyst complex component 2 [ Mus musculus (house mouse) ]

Gene ID: 66482, updated on 5-Jan-2023

Summary

Official Symbol
Exoc2provided by MGI
Official Full Name
exocyst complex component 2provided by MGI
Primary source
MGI:MGI:1913732
See related
Ensembl:ENSMUSG00000021357 AllianceGenome:MGI:1913732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sec5; Sec5l1; 2410030I24Rik
Summary
Enables protein N-terminus binding activity and small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane transport; exocytosis; and regulation of entry of bacterium into host cell. Predicted to act upstream of or within positive regulation of exocytosis. Predicted to be located in plasma membrane. Predicted to be part of exocyst. Is expressed in several structures, including early conceptus and genitourinary system. Orthologous to human EXOC2 (exocyst complex component 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 9.5), CNS E14 (RPKM 7.9) and 28 other tissues See more
Orthologs
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Genomic context

See Exoc2 in Genome Data Viewer
Location:
13; 13 A3.2
Exon count:
36
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (30972939..31162082, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (30789516..30974096, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 22 Neighboring gene interferon regulatory factor 4 Neighboring gene HUS1 checkpoint clamp component B Neighboring gene predicted gene, 35302 Neighboring gene RIKEN cDNA 4930401O12 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of exocyst ISO
Inferred from Sequence Orthology
more info
 
part_of exocyst NAS
Non-traceable Author Statement
more info
PubMed 
part_of exocyst TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
exocyst complex component 2
Names
SEC5 homolog
SEC5-like 1
exocyst complex component Sec5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360093.1NP_001347022.1  exocyst complex component 2

    Status: VALIDATED

    Source sequence(s)
    AL606764, AL645745
    Consensus CDS
    CCDS26420.1
    UniProtKB/Swiss-Prot
    Q9D4H1
    UniProtKB/TrEMBL
    A0A8C6HVV7
    Related
    ENSMUSP00000100010.2, ENSMUST00000102946.8
    Conserved Domains (2) summary
    pfam01833
    Location:891
    TIG; IPT/TIG domain
    pfam15469
    Location:200376
    Sec5; Exocyst complex component Sec5
  2. NM_025588.2NP_079864.1  exocyst complex component 2

    See identical proteins and their annotated locations for NP_079864.1

    Status: VALIDATED

    Source sequence(s)
    BC049102
    Consensus CDS
    CCDS26420.1
    UniProtKB/Swiss-Prot
    Q9D4H1
    UniProtKB/TrEMBL
    A0A8C6HVV7
    Related
    ENSMUSP00000021785.7, ENSMUST00000021785.8
    Conserved Domains (2) summary
    pfam01833
    Location:891
    TIG; IPT/TIG domain
    pfam15469
    Location:200376
    Sec5; Exocyst complex component Sec5

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    30972939..31162082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244328.3XP_011242630.1  exocyst complex component 2 isoform X1

    Conserved Domains (2) summary
    pfam01833
    Location:891
    TIG; IPT/TIG domain
    pfam15469
    Location:200376
    Sec5; Exocyst complex component Sec5
  2. XM_036158115.1XP_036014008.1  exocyst complex component 2 isoform X1

    Conserved Domains (2) summary
    pfam01833
    Location:891
    TIG; IPT/TIG domain
    pfam15469
    Location:200376
    Sec5; Exocyst complex component Sec5
  3. XM_036158116.1XP_036014009.1  exocyst complex component 2 isoform X1

    Conserved Domains (2) summary
    pfam01833
    Location:891
    TIG; IPT/TIG domain
    pfam15469
    Location:200376
    Sec5; Exocyst complex component Sec5
  4. XM_036158117.1XP_036014010.1  exocyst complex component 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9D4H1
    UniProtKB/TrEMBL
    A0A8C6HVV7
    Conserved Domains (2) summary
    pfam01833
    Location:891
    TIG; IPT/TIG domain
    pfam15469
    Location:200376
    Sec5; Exocyst complex component Sec5
  5. XM_017315565.3XP_017171054.1  exocyst complex component 2 isoform X4

    Conserved Domains (2) summary
    pfam01833
    Location:891
    TIG; IPT/TIG domain
    pfam15469
    Location:200374
    Sec5; Exocyst complex component Sec5
  6. XM_017315564.3XP_017171053.1  exocyst complex component 2 isoform X3

    Conserved Domains (2) summary
    pfam01833
    Location:891
    TIG; IPT/TIG domain
    pfam15469
    Location:200374
    Sec5; Exocyst complex component Sec5