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Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 [ Mus musculus (house mouse) ]

Gene ID: 66461, updated on 12-May-2024


Official Symbol
Ptpmt1provided by MGI
Official Full Name
protein tyrosine phosphatase, mitochondrial 1provided by MGI
Primary source
See related
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PLIP; 1110001D10Rik; 2810004N20Rik
Enables phosphatidylglycerophosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in cardiolipin biosynthetic process. Located in mitochondrion. Is expressed in several structures, including genitourinary system; gut; immune system; inner cell mass; and musculature. Orthologous to human PTPMT1 (protein tyrosine phosphatase mitochondrial 1). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in testis adult (RPKM 42.4), duodenum adult (RPKM 40.3) and 28 other tissues See more
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Genomic context

See Ptpmt1 in Genome Data Viewer
2 E1; 2 50.44 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (90741057..90748395, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (90910713..90918050, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit S3 Neighboring gene predicted gene, 54113 Neighboring gene kelch repeat and BTB (POZ) domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_05099 Neighboring gene CUGBP, Elav-like family member 1 Neighboring gene STARR-seq mESC enhancer starr_05101 Neighboring gene STARR-positive B cell enhancer mm9_chr2:90854051-90854352 Neighboring gene STARR-positive B cell enhancer ABC_E5944 Neighboring gene receptor-associated protein of the synapse Neighboring gene predicted gene 13778

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a


GeneRIFs: Gene References Into Functions

What's a GeneRIF?



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (6)  1 citation

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info

General protein information

Preferred Names
phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
PTEN-like phosphatase
phosphoinositide lipid phosphatase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025576.2NP_079852.1  phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

    See identical proteins and their annotated locations for NP_079852.1

    Status: VALIDATED

    Source sequence(s)
    AK014691, AK151972, AL672241
    Conserved Domains (1) summary
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000068.8 Reference GRCm39 C57BL/6J

    90741057..90748395 complement
    GenBank, FASTA, Sequence Viewer (Graphics)