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Fis1 fission, mitochondrial 1 [ Mus musculus (house mouse) ]

Gene ID: 66437, updated on 8-Feb-2024

Summary

Official Symbol
Fis1provided by MGI
Official Full Name
fission, mitochondrial 1provided by MGI
Primary source
MGI:MGI:1913687
See related
Ensembl:ENSMUSG00000019054 AllianceGenome:MGI:1913687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ttc11; 2010003O14Rik
Summary
Predicted to enable identical protein binding activity. Involved in mitochondrial fission. Located in mitochondrion. Is expressed in heart. Orthologous to human FIS1 (fission, mitochondrial 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 78.3), CNS E14 (RPKM 69.9) and 28 other tissues See more
Orthologs
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Genomic context

See Fis1 in Genome Data Viewer
Location:
5 G2; 5 76.06 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136982129..136995088)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136953275..136966234)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 22 Neighboring gene RIKEN cDNA 4933404O12 gene Neighboring gene STARR-seq mESC enhancer starr_14629 Neighboring gene STARR-seq mESC enhancer starr_14631 Neighboring gene STARR-positive B cell enhancer ABC_E10358 Neighboring gene claudin 15 Neighboring gene STARR-positive B cell enhancer ABC_E4795 Neighboring gene zinc finger, HIT domain containing 1 Neighboring gene procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autophagy of mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-mediated signaling using intracellular calcium source ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fission ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial fragmentation involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial fragmentation involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitochondrion organization ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endoplasmic reticulum calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fatty acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in peroxisome fission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peroxisome fission ISO
Inferred from Sequence Orthology
more info
 
involved_in peroxisome fission ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitochondrial fission 1 protein
Names
FIS1 homolog
TPR repeat protein 11
fission 1 (mitochondrial outer membrane) homolog
tetratricopeptide repeat domain 11
tetratricopeptide repeat protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163243.1NP_001156715.1  mitochondrial fission 1 protein isoform 2

    See identical proteins and their annotated locations for NP_001156715.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK008078, CA322565, CD774298
    Consensus CDS
    CCDS51669.1
    UniProtKB/TrEMBL
    G3X9U9
    Related
    ENSMUSP00000106723.2, ENSMUST00000111094.8
    Conserved Domains (1) summary
    cd12212
    Location:4116
    Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain
  2. NM_001347504.1NP_001334433.1  mitochondrial fission 1 protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC147987
    Consensus CDS
    CCDS84977.1
    UniProtKB/TrEMBL
    D3YZ32
    Related
    ENSMUSP00000106726.2, ENSMUST00000111097.8
  3. NM_025562.3NP_079838.1  mitochondrial fission 1 protein isoform 1

    See identical proteins and their annotated locations for NP_079838.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK008078, AW988976, CD774298
    Consensus CDS
    CCDS19757.1
    UniProtKB/Swiss-Prot
    Q9CQ92
    Related
    ENSMUSP00000019198.7, ENSMUST00000019198.7
    Conserved Domains (1) summary
    cd12212
    Location:9123
    Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    136982129..136995088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)