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Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 66435, updated on 25-Dec-2022

Summary

Official Symbol
Uggt2provided by MGI
Official Full Name
UDP-glucose glycoprotein glucosyltransferase 2provided by MGI
Primary source
MGI:MGI:1913685
See related
Ensembl:ENSMUSG00000042104 AllianceGenome:MGI:1913685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ugcgl2; 1810064L21Rik; 3110001A05Rik; 3110027P15Rik; A230065J02Rik
Summary
Predicted to enable UDP-glucose:glycoprotein glucosyltransferase activity and unfolded protein binding activity. Predicted to be involved in ER-associated misfolded protein catabolic process and protein N-linked glycosylation via asparagine. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum. Orthologous to human UGGT2 (UDP-glucose glycoprotein glucosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 4.9), CNS E14 (RPKM 4.9) and 20 other tissues See more
Orthologs
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Genomic context

See Uggt2 in Genome Data Viewer
Location:
14; 14 E4
Exon count:
48
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (119219177..119337208, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (118982006..119099796, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene DAZ interacting protein 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C3 Neighboring gene coiled-coil domain-containing protein 58 pseudogene Neighboring gene predicted gene, 16835 Neighboring gene heparan sulfate 6-O-sulfotransferase 3 Neighboring gene tera pseudogene Neighboring gene CD24a antigen pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-glucose:glycoprotein glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in ER-associated misfolded protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
UDP-glucose:glycoprotein glucosyltransferase 2
Names
UDP-glucose ceramide glucosyltransferase-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081252.2NP_001074721.2  UDP-glucose:glycoprotein glucosyltransferase 2 precursor

    See identical proteins and their annotated locations for NP_001074721.2

    Status: VALIDATED

    Source sequence(s)
    AC154760
    Consensus CDS
    CCDS37013.2
    UniProtKB/TrEMBL
    E9Q4X2
    Related
    ENSMUSP00000121249.2, ENSMUST00000156203.8
    Conserved Domains (2) summary
    cd06432
    Location:12191466
    GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
    pfam06427
    Location:241181
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    119219177..119337208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519376.3XP_006519439.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1

    Conserved Domains (6) summary
    pfam06427
    Location:10831189
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    pfam18400
    Location:36217
    Thioredoxin_12; Thioredoxin-like domain
    pfam18401
    Location:287394
    Thioredoxin_13; Thioredoxin-like domain
    pfam18402
    Location:428676
    Thioredoxin_14; Thioredoxin-like domain
    pfam18403
    Location:700922
    Thioredoxin_15; Thioredoxin-like domain
    pfam18404
    Location:12191417
    Glyco_transf_24; Glucosyltransferase 24
  2. XM_006519380.5XP_006519443.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X2

    See identical proteins and their annotated locations for XP_006519443.1

    Conserved Domains (6) summary
    pfam06427
    Location:10831189
    UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    pfam18400
    Location:36217
    Thioredoxin_12; Thioredoxin-like domain
    pfam18401
    Location:287394
    Thioredoxin_13; Thioredoxin-like domain
    pfam18402
    Location:428676
    Thioredoxin_14; Thioredoxin-like domain
    pfam18403
    Location:700922
    Thioredoxin_15; Thioredoxin-like domain
    pfam18404
    Location:12191235
    Glyco_transf_24; Glucosyltransferase 24

RNA

  1. XR_004938436.1 RNA Sequence

  2. XR_003950882.1 RNA Sequence

  3. XR_003950881.1 RNA Sequence

  4. XR_001781137.2 RNA Sequence

  5. XR_004938425.1 RNA Sequence

  6. XR_004938427.1 RNA Sequence

  7. XR_004938428.1 RNA Sequence

  8. XR_003950883.1 RNA Sequence

  9. XR_004938431.1 RNA Sequence

  10. XR_003950885.1 RNA Sequence

  11. XR_004938430.1 RNA Sequence

  12. XR_004938433.1 RNA Sequence

  13. XR_004938434.1 RNA Sequence

  14. XR_004938435.1 RNA Sequence

  15. XR_003950884.1 RNA Sequence

  16. XR_003950888.1 RNA Sequence

  17. XR_003950889.1 RNA Sequence

  18. XR_004938429.1 RNA Sequence

  19. XR_003950887.1 RNA Sequence

  20. XR_004938438.1 RNA Sequence

  21. XR_004938439.1 RNA Sequence

  22. XR_003950891.2 RNA Sequence

  23. XR_003950890.1 RNA Sequence

  24. XR_003950892.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_025561.1: Suppressed sequence

    Description
    NM_025561.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.