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Rtf2 replication termination factor 2 [ Mus musculus (house mouse) ]

Gene ID: 66404, updated on 11-Apr-2024


Official Symbol
Rtf2provided by MGI
Official Full Name
replication termination factor 2provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000027502 AllianceGenome:MGI:1913654
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rtfdc1; 1700067C04Rik; 2410001C21Rik; 5730427M17Rik
Predicted to enable DNA binding activity. Predicted to be involved in cellular response to hydroxyurea and regulation of DNA stability. Predicted to be located in replication fork. Predicted to be active in nucleus. Is expressed in embryo. Orthologous to human RTF2 (replication termination factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in subcutaneous fat pad adult (RPKM 28.4), placenta adult (RPKM 26.9) and 28 other tissues See more
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Genomic context

See Rtf2 in Genome Data Viewer
2 H3; 2 94.86 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (172282498..172311819)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (172440578..172469899)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene aurora kinase A Neighboring gene cleavage stimulation factor, 3' pre-RNA, subunit 1 Neighboring gene STARR-seq mESC enhancer starr_06572 Neighboring gene STARR-positive B cell enhancer ABC_E823 Neighboring gene Cas scaffolding protein family member 4 Neighboring gene uncharacterized LOC118568483 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:172259262-172259485 Neighboring gene STARR-positive B cell enhancer ABC_E3425 Neighboring gene glucosaminyl (N-acetyl) transferase family member 7 Neighboring gene family with sequence similarity 209 Neighboring gene STARR-seq mESC enhancer starr_06574 Neighboring gene STARR-seq mESC enhancer starr_06576 Neighboring gene predicted gene, 40009 Neighboring gene ribosomal protein S29 pseudogene

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
Process Evidence Code Pubs
involved_in DNA replication termination IBA
Inferred from Biological aspect of Ancestor
more info
involved_in cellular response to hydroxyurea ISO
Inferred from Sequence Orthology
more info
involved_in mitotic DNA replication termination IEA
Inferred from Electronic Annotation
more info
involved_in regulation of DNA stability ISO
Inferred from Sequence Orthology
more info
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
located_in replication fork ISO
Inferred from Sequence Orthology
more info

General protein information

Preferred Names
replication termination factor 2
UPF0549 protein C20orf43 homolog
likely orthologue of H. sapiens chromosome 20 open reading frame 43 (C20orf43)
protein RTF2 homolog
replication termination factor 2 domain containing 1
replication termination factor 2 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025542.2NP_079818.1  replication termination factor 2

    See identical proteins and their annotated locations for NP_079818.1


    Source sequence(s)
    Consensus CDS
    A2APA0, Q543D3, Q80X88, Q99K95, Q9CV27
    Q3TDK9, Q4V9T7
    ENSMUSP00000029005.4, ENSMUST00000029005.4
    Conserved Domains (1) summary
    Rtf2; Rtf2 RING-finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000068.8 Reference GRCm39 C57BL/6J

    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175297.2: Suppressed sequence

    NM_175297.2: This RefSeq was permanently suppressed because it is primarily intronic sequence.