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Nudt2 nudix hydrolase 2 [ Mus musculus (house mouse) ]

Gene ID: 66401, updated on 11-Oct-2022

Summary

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Official Symbol
Nudt2provided by MGI
Official Full Name
nudix hydrolase 2provided by MGI
Primary source
MGI:MGI:1913651
See related
Ensembl:ENSMUSG00000028443 AllianceGenome:MGI:1913651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APAH1; 2310051L06Rik
Summary
Predicted to enable bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity. Predicted to be involved in AMP biosynthetic process; ATP biosynthetic process; and apoptotic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to human NUDT2 (nudix hydrolase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 14.1), placenta adult (RPKM 10.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nudt2 in Genome Data Viewer
Location:
4; 4 A5
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41465085..41480926)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41465081..41480926)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-associated protein 1 Neighboring gene kinesin family member 24 Neighboring gene RIKEN cDNA 1110017D15 gene Neighboring gene myogenesis regulating glycosidase (putative)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NUDT2 initiates viral RNA degradation by removal of 5'-phosphates. Laudenbach BT, et al. Nat Commun, 2021 Nov 25. PMID 34824277, Free PMC Article
  2. Importin beta plays an essential role in the regulation of the LysRS-Ap(4)A pathway in immunologically activated mast cells. Carmi-Levy I, et al. Mol Cell Biol, 2011 May. PMID 21402779, Free PMC Article
  3. Ap4A induces apoptosis in human cultured cells. Vartanian A, et al. FEBS Lett, 1999 Jul 30. PMID 10452553
  4. The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms. Bailey S, et al. Structure, 2002 Apr. PMID 11937063
  5. Cloning, characterisation and crystallisation of a diadenosine 5',5"'-P(1),P(4)-tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans. Abdelghany HM, et al. Biochim Biophys Acta, 2001 Nov 26. PMID 11738085

See all (23) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NUDT2 initiates viral RNA degradation by removal of 5'-phosphates.
    Title: NUDT2 initiates viral RNA degradation by removal of 5'-phosphates.
  2. Ap4A hydrolase was found to translocate into the nuclei of mast cells following immunological activation; found its immunologically dependent association with importin beta
    Title: Importin beta plays an essential role in the regulation of the LysRS-Ap(4)A pathway in immunologically activated mast cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables bis(5'-nucleosyl)-tetraphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in AMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in ATP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
Names
ap4A hydrolase
ap4Aase
bis(5'-nucleosyl)-tetraphosphatase
diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase
diadenosine tetraphosphatase
nucleoside diphosphate-linked moiety X motif 2
nudix (nucleoside diphosphate linked moiety X)-type motif 2
nudix motif 2
NP_079815.2
XP_006538228.1
XP_011248384.1
XP_030109557.1
XP_036020201.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025539.2 → NP_079815.2  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

    See identical proteins and their annotated locations for NP_079815.2

    Status: VALIDATED

    Source sequence(s)
    AK018771, AK132532, CB845734
    Consensus CDS
    CCDS18061.1
    UniProtKB/Swiss-Prot
    P56380, Q9D6V2
    UniProtKB/TrEMBL
    A0A6P5PNW6, A0A8C6GJ26, Q3V1C8
    Related
    ENSMUSP00000030154.7, ENSMUST00000030154.7
    Conserved Domains (1) summary
    cd03428
    Location:2 → 140
    Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    41465085..41480926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164308.1 → XP_036020201.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

    UniProtKB/Swiss-Prot
    Q9D6V2
    UniProtKB/TrEMBL
    A0A6P5PNW6, A0A8C6GJ26
    Conserved Domains (1) summary
    cd03428
    Location:2 → 140
    Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...

  2. XM_011250082.4 → XP_011248384.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

    See identical proteins and their annotated locations for XP_011248384.1

    UniProtKB/Swiss-Prot
    P56380, Q9D6V2
    UniProtKB/TrEMBL
    A0A6P5PNW6, A0A8C6GJ26
    Conserved Domains (1) summary
    cd03428
    Location:2 → 140
    Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...

  3. XM_030253697.2 → XP_030109557.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

    UniProtKB/Swiss-Prot
    Q9D6V2
    UniProtKB/TrEMBL
    A0A6P5PNW6, A0A8C6GJ26
    Conserved Domains (1) summary
    cd03428
    Location:2 → 140
    Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...

  4. XM_006538165.4 → XP_006538228.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

    See identical proteins and their annotated locations for XP_006538228.1

    UniProtKB/Swiss-Prot
    P56380, Q9D6V2
    UniProtKB/TrEMBL
    A0A6P5PNW6, A0A8C6GJ26
    Conserved Domains (1) summary
    cd03428
    Location:2 → 140
    Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56380.3 GenPept UniProtKB/Swiss-Prot:P56380

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