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Sar1b secretion associated Ras related GTPase 1B [ Mus musculus (house mouse) ]

Gene ID: 66397, updated on 15-Jun-2024

Summary

Official Symbol
Sar1bprovided by MGI
Official Full Name
secretion associated Ras related GTPase 1Bprovided by MGI
Primary source
MGI:MGI:1913647
See related
Ensembl:ENSMUSG00000020386 AllianceGenome:MGI:1913647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CMRD; Sarb; Sara2; Sara1b; 2310075M17Rik; 2900019I22Rik
Summary
Predicted to enable GTPase activity. Predicted to be involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; intracellular protein transport; and regulation of intracellular transport. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and membrane. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Human ortholog(s) of this gene implicated in chylomicron retention disease. Orthologous to human SAR1B (secretion associated Ras related GTPase 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 51.6), bladder adult (RPKM 37.1) and 25 other tissues See more
Orthologs
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Genomic context

See Sar1b in Genome Data Viewer
Location:
11 B1.3; 11 31.41 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51654490..51682780)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51763663..51791953)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29427 Neighboring gene trafficking protein particle complex 2B Neighboring gene STARR-seq mESC enhancer starr_29428 Neighboring gene SEC24 homolog A, COPII coat complex component Neighboring gene predicted gene, 25291 Neighboring gene jade family PHD finger 2 Neighboring gene STARR-positive B cell enhancer ABC_E10673 Neighboring gene STARR-positive B cell enhancer mm9_chr11:51671514-51671815 Neighboring gene predicted gene, 30110 Neighboring gene predicted gene, 39820

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables amino acid sensor activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in COPII vesicle coating ISO
Inferred from Sequence Orthology
more info
 
involved_in COPII-coated vesicle cargo loading ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to leucine starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid export from cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in lipoprotein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipoprotein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein exit from endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of COPII vesicle coating IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of lipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of COPII vesicle coat ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GTP-binding protein SAR1b
Names
SAR1 gene homolog B
SAR1a gene homolog 2
SAR1b gene homolog
NP_079811.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025535.2NP_079811.1  GTP-binding protein SAR1b

    See identical proteins and their annotated locations for NP_079811.1

    Status: VALIDATED

    Source sequence(s)
    BB749343, BC082550, BY068863
    Consensus CDS
    CCDS24661.1
    UniProtKB/Swiss-Prot
    Q3UBL6, Q9CQC9
    UniProtKB/TrEMBL
    Q0VGU0, Q3U281
    Related
    ENSMUSP00000020653.6, ENSMUST00000020653.6
    Conserved Domains (1) summary
    cd00879
    Location:3197
    Sar1; Sar1 is an essential component of COPII vesicle coats

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    51654490..51682780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)