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Ahnak AHNAK nucleoprotein (desmoyokin) [ Mus musculus (house mouse) ]

Gene ID: 66395, updated on 23-Jun-2021

Summary

Official Symbol
Ahnakprovided by MGI
Official Full Name
AHNAK nucleoprotein (desmoyokin)provided by MGI
Primary source
MGI:MGI:1316648
See related
Ensembl:ENSMUSG00000069833
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DY6
Expression
Biased expression in bladder adult (RPKM 56.2), lung adult (RPKM 31.1) and 13 other tissues See more
Orthologs
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Genomic context

See Ahnak in Genome Data Viewer
Location:
19; 19 A
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8966640..9054299)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8989284..9076935)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (9063774..9151409)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene secretoglobin, family 1A, member 1 (uteroglobin) Neighboring gene predicted gene, 41805

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • 1110004P15Rik, 2310047C17Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S100 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity conferring elasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of RNA splicing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
NOT colocalizes_with T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell contact zone ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in costamere IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in costamere IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with membrane raft ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
neuroblast differentiation-associated protein AHNAK
Names
desmoyokin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039959.2NP_001035048.1  neuroblast differentiation-associated protein AHNAK isoform 3

    See identical proteins and their annotated locations for NP_001035048.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the shortest transcript and encodes the shortest isoform (3).
    Source sequence(s)
    AK045184, BC028439, EH104676
    Consensus CDS
    CCDS50384.1
    UniProtKB/TrEMBL
    G5E8K8, Q8BRB8, Q8R2L7
    Related
    ENSMUSP00000090632.4, ENSMUST00000092955.11
    Conserved Domains (1) summary
    cl00117
    Location:2391
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
  2. NM_001286518.1NP_001273447.1  neuroblast differentiation-associated protein AHNAK isoform 4

    See identical proteins and their annotated locations for NP_001273447.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon that results in differences in its 3' UTR and 3' coding region, compared to variant 3. The encoded isoform (4) has a longer an distinct C--terminus, compared to isoform 3.
    Source sequence(s)
    AK045184, BC028439, EH104676
    UniProtKB/TrEMBL
    Q8BRB8, Q8R2L7
    Related
    ENSMUST00000237033.2
    Conserved Domains (1) summary
    cl00117
    Location:2391
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
  3. NM_009643.2NP_033773.1  neuroblast differentiation-associated protein AHNAK isoform 1

    See identical proteins and their annotated locations for NP_033773.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks part of the 3' coding region and uses an alternate 3'-terminal exon, compared to variant 3. The encoded isoform (1) has a longer and distinct C-terminus, compared to isoform 3.
    Source sequence(s)
    AC130819, AK045184
    Consensus CDS
    CCDS29564.1
    UniProtKB/TrEMBL
    E9Q616, Q8BRB8
    Related
    ENSMUSP00000090633.3, ENSMUST00000092956.4
    Conserved Domains (3) summary
    COG2911
    Location:49025412
    TamB; Autotransporter translocation and assembly factor TamB [Intracellular trafficking, secretion, and vesicular transport]
    pfam05109
    Location:45914783
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl00117
    Location:2391
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

RNA

  1. NR_104460.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK009866, AK045184, AW492521, BC028439, EH104676
    Related
    ENSMUST00000237912.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8966640..9054299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527256.5XP_006527319.1  neuroblast differentiation-associated protein AHNAK isoform X3

    Conserved Domains (3) summary
    COG2911
    Location:25693079
    TamB; Autotransporter translocation and assembly factor TamB [Intracellular trafficking, secretion, and vesicular transport]
    pfam05109
    Location:22582450
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl00117
    Location:2391
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
  2. XM_017318272.2XP_017173761.1  neuroblast differentiation-associated protein AHNAK isoform X2

    Conserved Domains (3) summary
    COG2911
    Location:38564366
    TamB; Autotransporter translocation and assembly factor TamB [Intracellular trafficking, secretion, and vesicular transport]
    pfam05109
    Location:35453737
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl00117
    Location:2391
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
  3. XM_006527253.5XP_006527316.1  neuroblast differentiation-associated protein AHNAK isoform X1

    See identical proteins and their annotated locations for XP_006527316.1

    UniProtKB/TrEMBL
    E9Q616
    Conserved Domains (3) summary
    COG2911
    Location:49025412
    TamB; Autotransporter translocation and assembly factor TamB [Intracellular trafficking, secretion, and vesicular transport]
    pfam05109
    Location:45914783
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl00117
    Location:2391
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

RNA

  1. XR_877686.4 RNA Sequence

  2. XR_004940166.1 RNA Sequence

  3. XR_877685.4 RNA Sequence

  4. XR_877684.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175108.3: Suppressed sequence

    Description
    NM_175108.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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