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Iscu iron-sulfur cluster assembly enzyme [ Mus musculus (house mouse) ]

Gene ID: 66383, updated on 18-Apr-2019

Summary

Official Symbol
Iscuprovided by MGI
Official Full Name
iron-sulfur cluster assembly enzymeprovided by MGI
Primary source
MGI:MGI:1913633
See related
Ensembl:ENSMUSG00000025825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nifu; ISCU2; Nifun; AA407971; 2310020H20Rik
Expression
Ubiquitous expression in adrenal adult (RPKM 128.4), kidney adult (RPKM 126.9) and 28 other tissues See more
Orthologs

Genomic context

See Iscu in Genome Data Viewer
Location:
5; 5 F
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (113772812..113778282)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (114222821..114228291)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene FIC domain containing Neighboring gene squamous cell carcinoma antigen recognized by T cells 3 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene transmembrane protein 119 Neighboring gene predicted gene, 42004

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
2 iron, 2 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ferrous iron import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
positive regulation of aconitate hydratase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitochondrial electron transport, NADH to ubiquinone ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
iron-sulfur cluster assembly enzyme ISCU, mitochondrial
Names
IscU iron-sulfur cluster scaffold homolog
nifU-like N-terminal domain-containing protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363317.1NP_001350246.1  iron-sulfur cluster assembly enzyme ISCU, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132939, AI851358, AK083247
    Conserved Domains (1) summary
    PRK11325
    Location:50170
    PRK11325; scaffold protein; Provisional
  2. NM_025526.5NP_079802.1  iron-sulfur cluster assembly enzyme ISCU, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_079802.1

    Status: VALIDATED

    Source sequence(s)
    AC132939
    Consensus CDS
    CCDS19553.1
    UniProtKB/Swiss-Prot
    Q9D7P6
    Related
    ENSMUSP00000026937.5, ENSMUST00000026937.11
    Conserved Domains (1) summary
    PRK11325
    Location:36159
    PRK11325; scaffold protein; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    113772812..113778282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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