Format

Send to:

Choose Destination

Iscu iron-sulfur cluster assembly enzyme [ Mus musculus (house mouse) ]

Gene ID: 66383, updated on 21-Apr-2024

Summary

Official Symbol
Iscuprovided by MGI
Official Full Name
iron-sulfur cluster assembly enzymeprovided by MGI
Primary source
MGI:MGI:1913633
See related
Ensembl:ENSMUSG00000025825 AllianceGenome:MGI:1913633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nifu; ISCU2; Nifun; 2310020H20Rik
Summary
Predicted to enable 2 iron, 2 sulfur cluster binding activity; ferrous iron binding activity; and molecular adaptor activity. Predicted to be involved in several processes, including negative regulation of iron ion import across plasma membrane; positive regulation of aconitate hydratase activity; and positive regulation of mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrion. Orthologous to human ISCU (iron-sulfur cluster assembly enzyme). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 128.4), kidney adult (RPKM 126.9) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
5 F; 5 55.55 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113910479..113916349)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113772418..113778288)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2171 Neighboring gene FIC domain containing Neighboring gene squamous cell carcinoma antigen recognized by T cells 3 Neighboring gene STARR-seq mESC enhancer starr_14052 Neighboring gene STARR-positive B cell enhancer ABC_E9260 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene transmembrane protein 119 Neighboring gene predicted gene, 42004 Neighboring gene STARR-positive B cell enhancer ABC_E3601

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of iron-sulfur cluster assembly complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of mitochondrial iron-sulfur cluster assembly complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial iron-sulfur cluster assembly complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
iron-sulfur cluster assembly enzyme ISCU
Names
IscU iron-sulfur cluster scaffold homolog
iron-sulfur cluster assembly enzyme ISCU, mitochondrial
nifU-like N-terminal domain-containing protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363317.1NP_001350246.1  iron-sulfur cluster assembly enzyme ISCU isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132939, AI851358, AK083247
    Conserved Domains (1) summary
    PRK11325
    Location:50170
    PRK11325; scaffold protein; Provisional
  2. NM_025526.5NP_079802.1  iron-sulfur cluster assembly enzyme ISCU isoform 1 precursor

    See identical proteins and their annotated locations for NP_079802.1

    Status: VALIDATED

    Source sequence(s)
    AC132939
    Consensus CDS
    CCDS19553.1
    UniProtKB/Swiss-Prot
    Q4VBC7, Q8K344, Q9D7P6
    Related
    ENSMUSP00000026937.6, ENSMUST00000026937.12
    Conserved Domains (1) summary
    PRK11325
    Location:36159
    PRK11325; scaffold protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    113910479..113916349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254754.1XP_030110614.1  iron-sulfur cluster assembly enzyme ISCU isoform X1

    Conserved Domains (1) summary
    PRK11325
    Location:117221
    PRK11325; scaffold protein; Provisional
  2. XM_030254755.1XP_030110615.1  iron-sulfur cluster assembly enzyme ISCU isoform X2

    Conserved Domains (1) summary
    cl00528
    Location:50151
    IscU_like; Iron-sulfur cluster scaffold-like proteins