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SNRPF small nuclear ribonucleoprotein polypeptide F [ Homo sapiens (human) ]

Gene ID: 6636, updated on 23-Nov-2021

Summary

Official Symbol
SNRPFprovided by HGNC
Official Full Name
small nuclear ribonucleoprotein polypeptide Fprovided by HGNC
Primary source
HGNC:HGNC:11162
See related
Ensembl:ENSG00000139343 MIM:603541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMF; Sm-F; snRNP-F
Expression
Ubiquitous expression in bone marrow (RPKM 26.2), colon (RPKM 24.6) and 25 other tissues See more
Orthologs
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Genomic context

See SNRPF in Genome Data Viewer
Location:
12q23.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (95858952..95866140)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (96252730..96260883)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 247, pseudogene Neighboring gene SNRPF divergent transcript Neighboring gene long intergenic non-protein coding RNA 2410 Neighboring gene coiled-coil domain containing 38 Neighboring gene amidohydrolase domain containing 1 Neighboring gene AMDHD1 eExon liver enhancer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, small nuclear ribonucleoprotein polypeptide F (SNRPF), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spliceosomal snRNP assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of SMN-Sm protein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U1 snRNP IDA
Inferred from Direct Assay
more info
PubMed 
part_of U12-type spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of U2-type precatalytic spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of U4 snRNP IDA
Inferred from Direct Assay
more info
PubMed 
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of U7 snRNP IDA
Inferred from Direct Assay
more info
PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of methylosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of pICln-Sm protein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of small nuclear ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
small nuclear ribonucleoprotein F
Names
sm protein F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394209.1NP_001381138.1  small nuclear ribonucleoprotein F isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC090001
    Conserved Domains (1) summary
    cl00259
    Location:643
    Sm_like; Sm and related proteins
  2. NM_003095.5NP_003086.1  small nuclear ribonucleoprotein F isoform 1

    See identical proteins and their annotated locations for NP_003086.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC090001
    Consensus CDS
    CCDS9055.1
    UniProtKB/Swiss-Prot
    P62306
    Related
    ENSP00000266735.5, ENST00000266735.9
    Conserved Domains (1) summary
    cd01722
    Location:674
    Sm_F; Sm protein F

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    95858952..95866140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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