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Snw1 SNW domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 66354, updated on 12-May-2024

Summary

Official Symbol
Snw1provided by MGI
Official Full Name
SNW domain containing 1provided by MGI
Primary source
MGI:MGI:1913604
See related
Ensembl:ENSMUSG00000021039 AllianceGenome:MGI:1913604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SKIP; Skiip; NCoA-62; 2310008B08Rik
Summary
Predicted to enable several functions, including Notch binding activity; nuclear receptor binding activity; and transcription coactivator activity. Involved in cellular response to retinoic acid and positive regulation of neurogenesis. Acts upstream of or within skeletal muscle cell differentiation. Predicted to be located in chromatin; cytoplasm; and nuclear lumen. Predicted to be part of SMAD protein complex; U2-type catalytic step 2 spliceosome; and cyclin/CDK positive transcription elongation factor complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer and pancreatic cancer. Orthologous to human SNW1 (SNW domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 29.9), bladder adult (RPKM 19.2) and 23 other tissues See more
Orthologs
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Genomic context

See Snw1 in Genome Data Viewer
Location:
12 D2; 12 41.67 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (87496680..87519069, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (87449910..87472299, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene alkB homolog 1, histone H2A dioxygenase Neighboring gene microRNA 3068 Neighboring gene STARR-seq mESC enhancer starr_32889 Neighboring gene SRA stem-loop interacting RNA binding protein Neighboring gene neural regeneration protein Neighboring gene STARR-seq mESC enhancer starr_32890 Neighboring gene RNA exonuclease 1 homolog pseudogene Neighboring gene GLE1 RNA export mediator pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC55033

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding ISO
Inferred from Sequence Orthology
more info
 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear retinoic acid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear vitamin D receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vitamin D receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of retinoic acid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of vitamin D receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in retinoic acid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of SMAD protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin/CDK positive transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
SNW domain-containing protein 1
Names
SKI interacting protein
nuclear protein SkiP
ski-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025507.2NP_079783.2  SNW domain-containing protein 1

    See identical proteins and their annotated locations for NP_079783.2

    Status: VALIDATED

    Source sequence(s)
    AK009218, AK012384, AK166163
    Consensus CDS
    CCDS49121.1
    UniProtKB/Swiss-Prot
    Q9CSN1
    UniProtKB/TrEMBL
    A0A0B4J1E2
    Related
    ENSMUSP00000021428.8, ENSMUST00000021428.9
    Conserved Domains (1) summary
    pfam02731
    Location:178334
    SKIP_SNW; SKIP/SNW domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    87496680..87519069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)