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Aqp11 aquaporin 11 [ Mus musculus (house mouse) ]

Gene ID: 66333, updated on 5-Jan-2023

Summary

Official Symbol
Aqp11provided by MGI
Official Full Name
aquaporin 11provided by MGI
Primary source
MGI:MGI:1913583
See related
Ensembl:ENSMUSG00000042797 AllianceGenome:MGI:1913583
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sjds; 1700015P13Rik
Summary
Enables water channel activity. Involved in several processes, including cellular water homeostasis; negative regulation of ERAD pathway; and oxygen homeostasis. Acts upstream of or within endosomal lumen acidification; proximal tubule development; and water transport. Located in endoplasmic reticulum; perinuclear region of cytoplasm; and plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and immune system. Orthologous to human AQP11 (aquaporin 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 412.2), thymus adult (RPKM 162.8) and 6 other tissues See more
Orthologs
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Genomic context

See Aqp11 in Genome Data Viewer
Location:
7; 7 E1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (97375586..97387454, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (97726379..97738247, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene remodeling and spacing factor 1 Neighboring gene remodeling and spacing factor 1, opposite strand 2 Neighboring gene chloride channel, nucleotide-sensitive, 1A Neighboring gene p21 (RAC1) activated kinase 1 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene ubiquinol-cytochrome c reductase complex chaperone, CBP3 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
sudden juvenile death syndrome
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC144511, MGC144512

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glycerol channel activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables water channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables water channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within endosomal lumen acidification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hydrogen peroxide transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular oxygen homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular water homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular water homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_positive_effect protein glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within proximal tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proximal tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within water transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
aquaporin-11
Names
AQP-11
CG12251 gene product

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175105.3NP_780314.1  aquaporin-11

    See identical proteins and their annotated locations for NP_780314.1

    Status: PROVISIONAL

    Source sequence(s)
    AK075757
    Consensus CDS
    CCDS21463.1
    UniProtKB/Swiss-Prot
    Q8BHH1, Q8JZU1
    Related
    ENSMUSP00000146215.2, ENSMUST00000206389.2
    Conserved Domains (1) summary
    cl00200
    Location:46257
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    97375586..97387454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)