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Tmem208 transmembrane protein 208 [ Mus musculus (house mouse) ]

Gene ID: 66320, updated on 5-Mar-2024

Summary

Official Symbol
Tmem208provided by MGI
Official Full Name
transmembrane protein 208provided by MGI
Primary source
MGI:MGI:1913570
See related
Ensembl:ENSMUSG00000014856 AllianceGenome:MGI:1913570
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hspc171; 1700006C06Rik; 2610030K20Rik
Summary
Predicted to be involved in vacuolar protein processing. Predicted to act upstream of or within autophagy. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including adrenal gland; genitourinary system; liver; lung; and spleen. Orthologous to human TMEM208 (transmembrane protein 208). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 31.1), large intestine adult (RPKM 28.4) and 28 other tissues See more
Orthologs
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Genomic context

See Tmem208 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106052980..106062117)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105326341..105335485)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene engulfment and cell motility 3 Neighboring gene microRNA 328 Neighboring gene F-box and leucine-rich repeat protein 9 Neighboring gene STARR-positive B cell enhancer ABC_E11746 Neighboring gene formin homology 2 domain containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107871965-107872074 Neighboring gene predicted gene, 46049 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC25457

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in vacuolar protein processing IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378965.1NP_001365894.1  transmembrane protein 208 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC124584
    Conserved Domains (1) summary
    pfam05620
    Location:8162
    DUF788; Protein of unknown function (DUF788)
  2. NM_001378966.1NP_001365895.1  transmembrane protein 208 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124584
    Related
    ENSMUSP00000096052.3, ENSMUST00000098453.9
    Conserved Domains (1) summary
    pfam05620
    Location:8100
    DUF788; Protein of unknown function (DUF788)
  3. NM_001378967.1NP_001365896.1  transmembrane protein 208 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124584
    UniProtKB/TrEMBL
    D3Z7S5
    Related
    ENSMUSP00000104997.2, ENSMUST00000109372.3
    Conserved Domains (1) summary
    pfam05620
    Location:8100
    DUF788; Protein of unknown function (DUF788)
  4. NM_001378968.1NP_001365897.1  transmembrane protein 208 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC124584
    UniProtKB/TrEMBL
    S4R1H6
    Related
    ENSMUSP00000138470.2, ENSMUST00000153146.9
    Conserved Domains (1) summary
    pfam05620
    Location:8100
    DUF788; Protein of unknown function (DUF788)
  5. NM_025486.3NP_079762.1  transmembrane protein 208 isoform 3

    See identical proteins and their annotated locations for NP_079762.1

    Status: VALIDATED

    Source sequence(s)
    AC124584
    Consensus CDS
    CCDS22599.1
    UniProtKB/Swiss-Prot
    Q3V2H5, Q8R1F8, Q9CR96
    Related
    ENSMUSP00000015000.5, ENSMUST00000015000.12
    Conserved Domains (1) summary
    pfam05620
    Location:8156
    DUF788; Protein of unknown function (DUF788)

RNA

  1. NR_166208.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124584
  2. NR_166209.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124584

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106052980..106062117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531277.5XP_006531340.1  transmembrane protein 208 isoform X1

    See identical proteins and their annotated locations for XP_006531340.1

    UniProtKB/TrEMBL
    S4R1H6
    Conserved Domains (1) summary
    pfam05620
    Location:8100
    DUF788; Protein of unknown function (DUF788)