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Cenpw centromere protein W [ Mus musculus (house mouse) ]

Gene ID: 66311, updated on 5-Mar-2024

Summary

Official Symbol
Cenpwprovided by MGI
Official Full Name
centromere protein Wprovided by MGI
Primary source
MGI:MGI:1913561
See related
Ensembl:ENSMUSG00000075266 AllianceGenome:MGI:1913561
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cug2; 2610036L11Rik
Summary
Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be involved in chromosome segregation; kinetochore assembly; and mitotic cell cycle. Predicted to act upstream of or within cell division. Predicted to be located in chromosome, centromeric region. Predicted to be active in kinetochore and nucleoplasm. Is expressed in several structures, including central nervous system and retina nuclear layer. Orthologous to human CENPW (centromere protein W). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 9.7), CNS E11.5 (RPKM 8.7) and 20 other tissues See more
Orthologs
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Genomic context

See Cenpw in Genome Data Viewer
Location:
10 A4; 10 16.93 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (30072005..30076599, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (30196009..30200603, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26187 Neighboring gene aldolase 1 A retrogene 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26188 Neighboring gene STARR-seq mESC enhancer starr_26189 Neighboring gene STARR-seq mESC enhancer starr_26190 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_26192 Neighboring gene STARR-seq mESC enhancer starr_26193 Neighboring gene STARR-seq mESC enhancer starr_26194 Neighboring gene STARR-seq mESC enhancer starr_26195 Neighboring gene makorin, ring finger protein, 2 pseudogene Neighboring gene predicted gene, 40622

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in kinetochore assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in kinetochore assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
centromere protein W
Names
CENP-W
cancer-up-regulated gene 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109747.1NP_001103217.1  centromere protein W

    See identical proteins and their annotated locations for NP_001103217.1

    Status: VALIDATED

    Source sequence(s)
    AK141272, BF453953, BG804382
    Consensus CDS
    CCDS35876.1
    UniProtKB/Swiss-Prot
    Q3URR0
    UniProtKB/TrEMBL
    A0A1L1SQB9, B2RVH1
    Related
    ENSMUSP00000097565.5, ENSMUST00000099985.6
    Conserved Domains (1) summary
    pfam15510
    Location:186
    CENP-W; Centromere kinetochore component W

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    30072005..30076599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512814.4XP_006512877.1  centromere protein W isoform X1

    Conserved Domains (1) summary
    pfam15510
    Location:140
    CENP-W; CENP-W protein