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Dpy30 dpy-30, histone methyltransferase complex regulatory subunit [ Mus musculus (house mouse) ]

Gene ID: 66310, updated on 5-Jul-2025
Official Symbol
Dpy30provided by MGI
Official Full Name
dpy-30, histone methyltransferase complex regulatory subunitprovided by MGI
Primary source
MGI:MGI:1913560
See related
Ensembl:ENSMUSG00000024067 AllianceGenome:MGI:1913560
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810410M20Rik
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in endosomal transport and transcription initiation-coupled chromatin remodeling. Predicted to be located in nucleoplasm and trans-Golgi network. Predicted to be part of MLL1 complex; MLL3/4 complex; and Set1C/COMPASS complex. Is expressed in several structures, including alimentary system; cerebral cortex; lung; nose; and submandibular gland primordium. Orthologous to human DPY30 (dpy-30 histone methyltransferase complex regulatory subunit). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in liver E14 (RPKM 36.7), testis adult (RPKM 34.1) and 28 other tissues See more
Orthologs
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See Dpy30 in Genome Data Viewer
Location:
17 E2; 17 45.64 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (74606469..74630939, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (74299474..74323944, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mediator of cell motility 1 Neighboring gene F-box protein 34 pseudogene Neighboring gene predicted gene, 52299 Neighboring gene STARR-seq mESC enhancer starr_43214 Neighboring gene STARR-seq mESC enhancer starr_43216 Neighboring gene STARR-positive B cell enhancer ABC_E9964 Neighboring gene predicted gene, 31328 Neighboring gene predicted gene 9349

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in endosomal transport IEA
Inferred from Electronic Annotation
more info
 
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
 
involved_in endosomal transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transcription initiation-coupled chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription initiation-coupled chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of MLL1 complex IEA
Inferred from Electronic Annotation
more info
 
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of MLL1/2 complex IEA
Inferred from Electronic Annotation
more info
 
part_of MLL1/2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of MLL3/4 complex IEA
Inferred from Electronic Annotation
more info
 
part_of MLL3/4 complex ISO
Inferred from Sequence Orthology
more info
 
part_of Set1C/COMPASS complex IEA
Inferred from Electronic Annotation
more info
 
part_of Set1C/COMPASS complex ISO
Inferred from Sequence Orthology
more info
 
part_of Set1C/COMPASS complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of histone methyltransferase complex IEA
Inferred from Electronic Annotation
more info
 
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of histone methyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
protein dpy-30 homolog
Names
dosage compensation-related protein DPY30
dpy-30 homolog
dpy-30-like protein
dpy-30L

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146222.1NP_001139694.1  protein dpy-30 homolog

    See identical proteins and their annotated locations for NP_001139694.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK013073, BX518196
    Consensus CDS
    CCDS28970.1
    UniProtKB/Swiss-Prot
    Q99LT0
    UniProtKB/TrEMBL
    Q7TQ15
    Related
    ENSMUSP00000108190.4, ENSMUST00000112571.5
    Conserved Domains (1) summary
    pfam05186
    Location:5293
    Dpy-30; Dpy-30 motif
  2. NM_001146223.1NP_001139695.1  protein dpy-30 homolog

    See identical proteins and their annotated locations for NP_001139695.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK013073, AK077902, AV460563
    Consensus CDS
    CCDS28970.1
    UniProtKB/Swiss-Prot
    Q99LT0
    UniProtKB/TrEMBL
    Q7TQ15
    Related
    ENSMUSP00000156795.2, ENSMUST00000233581.2
    Conserved Domains (1) summary
    pfam05186
    Location:5293
    Dpy-30; Dpy-30 motif
  3. NM_001146224.1NP_001139696.1  protein dpy-30 homolog

    See identical proteins and their annotated locations for NP_001139696.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK003688, AK013073, BY123406
    Consensus CDS
    CCDS28970.1
    UniProtKB/Swiss-Prot
    Q99LT0
    UniProtKB/TrEMBL
    Q7TQ15
    Related
    ENSMUSP00000156830.2, ENSMUST00000232687.2
    Conserved Domains (1) summary
    pfam05186
    Location:5293
    Dpy-30; Dpy-30 motif
  4. NM_024428.4NP_077746.3  protein dpy-30 homolog

    See identical proteins and their annotated locations for NP_077746.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK013073, BU961422
    Consensus CDS
    CCDS28970.1
    UniProtKB/Swiss-Prot
    Q99LT0
    UniProtKB/TrEMBL
    Q7TQ15
    Related
    ENSMUSP00000126702.2, ENSMUST00000164832.9
    Conserved Domains (1) summary
    pfam05186
    Location:5293
    Dpy-30; Dpy-30 motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    74606469..74630939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)