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Dpy30 dpy-30, histone methyltransferase complex regulatory subunit [ Mus musculus (house mouse) ]

Gene ID: 66310, updated on 8-Dec-2022

Summary

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Official Symbol
Dpy30provided by MGI
Official Full Name
dpy-30, histone methyltransferase complex regulatory subunitprovided by MGI
Primary source
MGI:MGI:1913560
See related
Ensembl:ENSMUSG00000024067 AllianceGenome:MGI:1913560
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810410M20Rik
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in endosomal transport; histone H3-K4 methylation; and subtelomeric heterochromatin assembly. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleoplasm and trans-Golgi network. Predicted to be part of MLL3/4 complex and Set1C/COMPASS complex. Is expressed in alimentary system; liver; lung; nose; and renal cortex. Orthologous to human DPY30 (dpy-30 histone methyltransferase complex regulatory subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 36.7), testis adult (RPKM 34.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dpy30 in Genome Data Viewer
Location:
17; 17 E2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (74606469..74630939, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (74299474..74323944, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mediator of cell motility 1 Neighboring gene F-box protein 34 pseudogene Neighboring gene predicted gene, 52299 Neighboring gene predicted gene, 31328 Neighboring gene predicted gene 9349

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of chromatin modulator Dpy30 in osteoclast differentiation and function. Zhao Y, et al. Bone, 2022 Jun. PMID 35307321,
  2. DPY30 functions in glucose homeostasis via integrating activated histone epigenetic modifications. Liu B. Biochem Biophys Res Commun, 2018 Dec 9. PMID 30448059
  3. Hijacking a key chromatin modulator creates epigenetic vulnerability for MYC-driven cancer. Yang Z, et al. J Clin Invest, 2018 Aug 1. PMID 29870403, Free PMC Article
  4. Dpy30 is critical for maintaining the identity and function of adult hematopoietic stem cells. Yang Z, et al. J Exp Med, 2016 Oct 17. PMID 27647347, Free PMC Article
  5. Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Jiang H, et al. Cell, 2011 Feb 18. PMID 21335234, Free PMC Article

See all (42) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Ash2l SDI Domain Is Required to Maintain the Stability and Binding of DPY30.
    Title: The Ash2l SDI Domain Is Required to Maintain the Stability and Binding of DPY30.
  2. Role of chromatin modulator Dpy30 in osteoclast differentiation and function.
    Title: Role of chromatin modulator Dpy30 in osteoclast differentiation and function.
  3. A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells.
    Title: A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells.
  4. These results reveal a critical role of DPY30 in glucose homeostasis.
    Title: DPY30 functions in glucose homeostasis via integrating activated histone epigenetic modifications.
  5. Dpy30-deficient hematopoietic stem and progenitor cells cannot differentiate or efficiently up-regulate lineage-regulatory genes, and eventually fail to sustain for long term.
    Title: Dpy30 is critical for maintaining the identity and function of adult hematopoietic stem cells.
  6. Dpy30 role in cellular reprogramming and its interactions with Set1 complex
    Title: Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors.
  7. Results indicate an essential functional role for Dpy-30 and SET1/MLL complex-mediated H3K4 methylation, as a component of the bivalent mark, at developmental genes during the embryonic stem cells fate transitions.
    Title: Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of MLL1/2 complex ISO
Inferred from Sequence Orthology
more info
  
part_of MLL3/4 complex ISO
Inferred from Sequence Orthology
more info
  
part_of Set1C/COMPASS complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein dpy-30 homolog
Names
dosage compensation-related protein DPY30
dpy-30 homolog
dpy-30-like protein
dpy-30L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146222.1 → NP_001139694.1  protein dpy-30 homolog

    See identical proteins and their annotated locations for NP_001139694.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK013073, BX518196
    Consensus CDS
    CCDS28970.1
    UniProtKB/Swiss-Prot
    Q99LT0
    UniProtKB/TrEMBL
    A0A6P5NQH7, A0A8C6HTT8
    Related
    ENSMUSP00000108190.4, ENSMUST00000112571.5
    Conserved Domains (1) summary
    pfam05186
    Location:52 → 93
    Dpy-30; Dpy-30 motif

  2. NM_001146223.1 → NP_001139695.1  protein dpy-30 homolog

    See identical proteins and their annotated locations for NP_001139695.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK013073, AK077902, AV460563
    Consensus CDS
    CCDS28970.1
    UniProtKB/Swiss-Prot
    Q99LT0
    UniProtKB/TrEMBL
    A0A6P5NQH7, A0A8C6HTT8
    Related
    ENSMUSP00000156795.2, ENSMUST00000233581.2
    Conserved Domains (1) summary
    pfam05186
    Location:52 → 93
    Dpy-30; Dpy-30 motif

  3. NM_001146224.1 → NP_001139696.1  protein dpy-30 homolog

    See identical proteins and their annotated locations for NP_001139696.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK003688, AK013073, BY123406
    Consensus CDS
    CCDS28970.1
    UniProtKB/Swiss-Prot
    Q99LT0
    UniProtKB/TrEMBL
    A0A6P5NQH7, A0A8C6HTT8
    Related
    ENSMUSP00000156830.2, ENSMUST00000232687.2
    Conserved Domains (1) summary
    pfam05186
    Location:52 → 93
    Dpy-30; Dpy-30 motif

  4. NM_024428.4 → NP_077746.3  protein dpy-30 homolog

    See identical proteins and their annotated locations for NP_077746.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK013073, BU961422
    Consensus CDS
    CCDS28970.1
    UniProtKB/Swiss-Prot
    Q99LT0
    UniProtKB/TrEMBL
    A0A6P5NQH7, A0A8C6HTT8
    Related
    ENSMUSP00000126702.2, ENSMUST00000164832.9
    Conserved Domains (1) summary
    pfam05186
    Location:52 → 93
    Dpy-30; Dpy-30 motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    74606469..74630939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LT0.1 GenPept UniProtKB/Swiss-Prot:Q99LT0

Gene LinkOut

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