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Haus2 HAUS augmin-like complex, subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 66296, updated on 5-Mar-2024

Summary

Official Symbol
Haus2provided by MGI
Official Full Name
HAUS augmin-like complex, subunit 2provided by MGI
Primary source
MGI:MGI:1913546
See related
Ensembl:ENSMUSG00000027285 AllianceGenome:MGI:1913546
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cep27; 1700101G24Rik; 2410007P03Rik
Summary
Predicted to be involved in centrosome cycle; microtubule nucleation; and spindle assembly. Predicted to act upstream of or within cell division. Located in spindle microtubule. Orthologous to human HAUS2 (HAUS augmin like complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 7.6), CNS E11.5 (RPKM 6.0) and 25 other tissues See more
Orthologs
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Genomic context

See Haus2 in Genome Data Viewer
Location:
2 E5; 2 60.37 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120439863..120452041)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120609382..120621560)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05509 Neighboring gene zinc finger protein 106 Neighboring gene STARR-seq mESC enhancer starr_05510 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120393240-120393349 Neighboring gene STARR-seq mESC enhancer starr_05511 Neighboring gene synaptosomal-associated protein 23 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120435029-120435138 Neighboring gene STARR-seq mESC enhancer starr_05512 Neighboring gene STARR-positive B cell enhancer ABC_E414 Neighboring gene leucine rich repeat containing 57 Neighboring gene StAR related lipid transfer domain containing 9 Neighboring gene STARR-seq mESC enhancer starr_05514 Neighboring gene codanin 1 Neighboring gene tau tubulin kinase 2 Neighboring gene STARR-seq mESC enhancer starr_05516 Neighboring gene STARR-positive B cell enhancer ABC_E3396

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule organizing center organization IEA
Inferred from Electronic Annotation
more info
 
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spindle assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of HAUS complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of HAUS complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitotic spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitotic spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
HAUS augmin-like complex subunit 2
Names
centrosomal protein 27
centrosomal protein of 27 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290807.1NP_001277736.1  HAUS augmin-like complex subunit 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK007106, AL772299, BC086677, BP766698
    Consensus CDS
    CCDS71120.1
    UniProtKB/Swiss-Prot
    Q9CQS9
    Related
    ENSMUSP00000106334.2, ENSMUST00000110706.2
    Conserved Domains (1) summary
    pfam15003
    Location:1158
    HAUS2; HAUS augmin-like complex subunit 2
  2. NM_001290808.1NP_001277737.1  HAUS augmin-like complex subunit 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK012779, AL772299, BP766698, BY711279
    Conserved Domains (1) summary
    pfam15003
    Location:196
    HAUS2; HAUS augmin-like complex subunit 2
  3. NM_025475.3NP_079751.1  HAUS augmin-like complex subunit 2 isoform a

    See identical proteins and their annotated locations for NP_079751.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK012779, AL772299, BC086677, BP766698, BY711279
    Consensus CDS
    CCDS16624.1
    UniProtKB/Swiss-Prot
    A2AKH8, A2AKI1, Q3V1R1, Q9CQS9, Q9CRI2, Q9D9D0
    Related
    ENSMUSP00000117299.2, ENSMUST00000124187.8
    Conserved Domains (1) summary
    pfam15003
    Location:8198
    HAUS2; HAUS augmin-like complex subunit 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    120439863..120452041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162447.1XP_036018340.1  HAUS augmin-like complex subunit 2 isoform X1

    Conserved Domains (1) summary
    pfam15003
    Location:196
    HAUS2; HAUS augmin-like complex subunit 2