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Fam3a FAM3 metabolism regulating signaling molecule A [ Mus musculus (house mouse) ]

Gene ID: 66294, updated on 6-Jun-2024

Summary

Official Symbol
Fam3aprovided by MGI
Official Full Name
FAM3 metabolism regulating signaling molecule Aprovided by MGI
Primary source
MGI:MGI:1913544
See related
Ensembl:ENSMUSG00000031399 AllianceGenome:MGI:1913544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810037C20Rik
Summary
Predicted to be involved in antifungal humoral response; antimicrobial humoral immune response mediated by antimicrobial peptide; and negative regulation of antifungal innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human FAM3A (FAM3 metabolism regulating signaling molecule A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 19.5), genital fat pad adult (RPKM 19.1) and 28 other tissues See more
Orthologs
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Genomic context

See Fam3a in Genome Data Viewer
Location:
X A7.3; X 38.0 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73427816..73436856, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74384210..74393274, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted readthrough transcript (NMD candidate), 44504 Neighboring gene ubiquitin-like 4A Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 3 Neighboring gene inhibitor of kappaB kinase gamma Neighboring gene STARR-seq mESC enhancer starr_47367 Neighboring gene glucose-6-phosphate dehydrogenase X-linked Neighboring gene STARR-positive B cell enhancer ABC_E11050 Neighboring gene predicted gene, 54057

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Clone Names

  • MGC30343

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein FAM3A
Names
family with sequence similarity 3, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313725.2NP_001300654.1  protein FAM3A isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL807376
    Consensus CDS
    CCDS41022.1
    UniProtKB/Swiss-Prot
    Q9D8T0
    UniProtKB/TrEMBL
    A0A158SIT7, I7HJS7
    Related
    ENSMUSP00000114748.2, ENSMUST00000122894.8
    Conserved Domains (1) summary
    cd13940
    Location:55224
    ILEI_FAM3C; Interleukin-like EMT inducer
  2. NM_001379181.2NP_001366110.1  protein FAM3A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL807376
    UniProtKB/TrEMBL
    I7HJS7
    Conserved Domains (1) summary
    cd13940
    Location:55249
    ILEI_FAM3C; Interleukin-like EMT inducer
  3. NM_001379182.2NP_001366111.1  protein FAM3A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL807376
    Conserved Domains (1) summary
    cd13940
    Location:14183
    ILEI_FAM3C; Interleukin-like EMT inducer
  4. NM_001403517.1NP_001390446.1  protein FAM3A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL807376
    UniProtKB/TrEMBL
    I7HJS7
  5. NM_001403518.1NP_001390447.1  protein FAM3A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL807376
    UniProtKB/TrEMBL
    I7HJS7, I7HPY1
    Related
    ENSMUSP00000109775.2, ENSMUST00000114139.8
  6. NM_001403519.1NP_001390448.1  protein FAM3A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL807376
  7. NM_001403521.1NP_001390450.1  protein FAM3A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL807376
  8. NM_001403522.1NP_001390451.1  protein FAM3A isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AL807376
  9. NM_001403523.1NP_001390452.1  protein FAM3A isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AL807376
  10. NM_025473.5NP_079749.1  protein FAM3A isoform 1 precursor

    See identical proteins and their annotated locations for NP_079749.1

    Status: VALIDATED

    Source sequence(s)
    AL807376
    Consensus CDS
    CCDS41022.1
    UniProtKB/Swiss-Prot
    Q9D8T0
    UniProtKB/TrEMBL
    A0A158SIT7, I7HJS7
    Related
    ENSMUSP00000109779.4, ENSMUST00000114143.10
    Conserved Domains (1) summary
    cd13940
    Location:55224
    ILEI_FAM3C; Interleukin-like EMT inducer

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    73427816..73436856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247660.4XP_011245962.1  protein FAM3A isoform X2

    Conserved Domains (1) summary
    cd13940
    Location:14208
    ILEI_FAM3C; Interleukin-like EMT inducer