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SNRPB small nuclear ribonucleoprotein polypeptides B and B1 [ Homo sapiens (human) ]

Gene ID: 6628, updated on 11-Sep-2019

Summary

Official Symbol
SNRPBprovided by HGNC
Official Full Name
small nuclear ribonucleoprotein polypeptides B and B1provided by HGNC
Primary source
HGNC:HGNC:11153
See related
Ensembl:ENSG00000125835 MIM:182282
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COD; CCMS; SNRPB1; SmB/B'; Sm-B/B'; snRNP-B; SmB/SmB'
Summary
The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 101.8), lymph node (RPKM 67.1) and 25 other tissues See more
Orthologs

Genomic context

See SNRPB in Genome Data Viewer
Location:
20p13
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (2461642..2470789, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (2442281..2451499, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372503 Neighboring gene transglutaminase 3 Neighboring gene transglutaminase 6 Neighboring gene small nucleolar RNA, C/D box 119 Neighboring gene zinc finger protein 343 Neighboring gene uncharacterized LOC105372504 Neighboring gene transmembrane channel like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat U2 snRNPs interact with the HIV-1 Tat cofactor TAT-SF1 and stimulate transcription from the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
U1 snRNP binding IEA
Inferred from Electronic Annotation
more info
 
U2 snRNP binding IEA
Inferred from Electronic Annotation
more info
 
histone pre-mRNA DCP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
telomerase RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing TAS
Traceable Author Statement
more info
PubMed 
brain development IEA
Inferred from Electronic Annotation
more info
 
histone mRNA metabolic process TAS
Traceable Author Statement
more info
 
import into nucleus TAS
Traceable Author Statement
more info
 
mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
protein methylation IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal snRNP assembly IDA
Inferred from Direct Assay
more info
PubMed 
spliceosomal snRNP assembly TAS
Traceable Author Statement
more info
 
termination of RNA polymerase II transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
SMN-Sm protein complex IDA
Inferred from Direct Assay
more info
PubMed 
U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U1 snRNP IDA
Inferred from Direct Assay
more info
PubMed 
U12-type spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 
U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
U2-type precatalytic spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U4 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U4 snRNP IDA
Inferred from Direct Assay
more info
PubMed 
U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U7 snRNP IDA
Inferred from Direct Assay
more info
PubMed 
catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
histone pre-mRNA 3'end processing complex IEA
Inferred from Electronic Annotation
more info
 
methylosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
small nuclear ribonucleoprotein complex TAS
Traceable Author Statement
more info
PubMed 
spliceosomal complex TAS
Traceable Author Statement
more info
PubMed 
telomerase holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
small nuclear ribonucleoprotein-associated proteins B and B'
Names
B polypeptide of Sm protein
Sm protein B/B'
sm-B/Sm-B'
small nuclear ribonucleoprotein polypeptide B
small nuclear ribonucleoprotein polypeptides B and B'

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042057.1 RefSeqGene

    Range
    5065..14212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003091.4NP_003082.1  small nuclear ribonucleoprotein-associated proteins B and B' isoform B

    See identical proteins and their annotated locations for NP_003082.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, that causes a frameshift. The resulting isoform (B) is shorter and has a distinct C-terminus as compared to isoform B'.
    Source sequence(s)
    BM559678, X17567
    Consensus CDS
    CCDS13027.1
    UniProtKB/Swiss-Prot
    P14678
    UniProtKB/TrEMBL
    Q66K91
    Related
    ENSP00000370746.2, ENST00000381342.6
    Conserved Domains (1) summary
    cd01717
    Location:583
    Sm_B; Sm protein B
  2. NM_198216.2NP_937859.1  small nuclear ribonucleoprotein-associated proteins B and B' isoform B'

    See identical proteins and their annotated locations for NP_937859.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (B').
    Source sequence(s)
    BM559678, X17568
    Consensus CDS
    CCDS13026.1
    UniProtKB/Swiss-Prot
    P14678
    Related
    ENSP00000412566.2, ENST00000438552.6
    Conserved Domains (1) summary
    cd01717
    Location:583
    Sm_B; Sm protein B

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    2461642..2470789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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