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Retreg1 reticulophagy regulator 1 [ Mus musculus (house mouse) ]

Gene ID: 66270, updated on 12-May-2024

Summary

Official Symbol
Retreg1provided by MGI
Official Full Name
reticulophagy regulator 1provided by MGI
Primary source
MGI:MGI:1913520
See related
Ensembl:ENSMUSG00000022270 AllianceGenome:MGI:1913520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam134b; Retreg1d; 1810015C04Rik
Summary
Involved in negative regulation of neuron apoptotic process and reticulophagy. Acts upstream of or within mitophagy and white fat cell differentiation. Located in cis-Golgi network. Is expressed in several structures, including alimentary system; central nervous system; ganglia; metanephros; and reproductive system. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2B. Orthologous to human RETREG1 (reticulophagy regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 11.8), testis adult (RPKM 10.0) and 26 other tissues See more
Orthologs
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Genomic context

See Retreg1 in Genome Data Viewer
Location:
15 B1; 15 9.59 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (25840795..25973782)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (25843298..25973696)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene myosin X Neighboring gene PCNA-associated factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_38176 Neighboring gene STARR-seq mESC enhancer starr_38182 Neighboring gene STARR-seq mESC enhancer starr_38185 Neighboring gene STARR-seq mESC enhancer starr_38189 Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene 15_175.1 Neighboring gene STARR-seq mESC enhancer starr_38200 Neighboring gene microRNA 7212 Neighboring gene STARR-positive B cell enhancer ABC_E7362 Neighboring gene predicted gene, 53887 Neighboring gene STARR-positive B cell enhancer mm9_chr15:25946080-25946381 Neighboring gene zinc finger protein 622 Neighboring gene STARR-seq mESC enhancer starr_38204 Neighboring gene predicted gene, 41279 Neighboring gene predicted gene, 57625

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endoplasmic reticulum-autophagosome adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
reticulophagy regulator 1
Names
family with sequence similarity 134, member B
protein FAM134B
reticulophagy receptor 1
reticulophagy receptor Fam134b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034851.2NP_001030023.1  reticulophagy regulator 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC162303, AK015182, BY779369, CB724233
    Consensus CDS
    CCDS37050.1
    UniProtKB/Swiss-Prot
    E9QPM1, Q7TMY5, Q8VE91, Q9CUJ4, Q9D8Z5
    Related
    ENSMUSP00000022881.8, ENSMUST00000022881.15
    Conserved Domains (1) summary
    pfam02453
    Location:68216
    Reticulon; Reticulon
  2. NM_001277315.1NP_001264244.1  reticulophagy regulator 1 isoform 2

    See identical proteins and their annotated locations for NP_001264244.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC162303, AK167327
    Consensus CDS
    CCDS37051.1
    UniProtKB/Swiss-Prot
    Q8VE91
    Related
    ENSMUSP00000154471.2, ENSMUST00000227275.2
    Conserved Domains (1) summary
    cl26593
    Location:319356
    DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
  3. NM_001277316.1NP_001264245.1  reticulophagy regulator 1 isoform 3

    See identical proteins and their annotated locations for NP_001264245.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC162303, AI645997, AK146972
    Consensus CDS
    CCDS88741.1
    UniProtKB/Swiss-Prot
    Q8VE91
    Related
    ENSMUSP00000154765.2, ENSMUST00000226438.2
    Conserved Domains (2) summary
    TIGR00600
    Location:137248
    rad2; DNA excision repair protein (rad2)
    pfam09849
    Location:327364
    DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
  4. NM_001277317.1NP_001264246.1  reticulophagy regulator 1 isoform 4

    See identical proteins and their annotated locations for NP_001264246.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC162303, AK007506
    Consensus CDS
    CCDS88742.1
    UniProtKB/Swiss-Prot
    Q8VE91
    Related
    ENSMUSP00000154070.2, ENSMUST00000228306.2
    Conserved Domains (2) summary
    TIGR00600
    Location:119230
    rad2; DNA excision repair protein (rad2)
    pfam09849
    Location:309346
    DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)
  5. NM_001277318.1NP_001264247.1  reticulophagy regulator 1 isoform 5

    See identical proteins and their annotated locations for NP_001264247.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (5) has a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC131178, AC162303
    Conserved Domains (1) summary
    cl41772
    Location:184
    Arl6IP1_RETR3-like; ADP-ribosylation factor-like protein 6-interacting protein 1, Reticulophagy regulator 3, and similar proteins
  6. NM_025459.3NP_079735.2  reticulophagy regulator 1 isoform 2

    See identical proteins and their annotated locations for NP_079735.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus, compared to isoform 1. Both variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC162303
    Consensus CDS
    CCDS37051.1
    UniProtKB/Swiss-Prot
    Q8VE91
    Related
    ENSMUSP00000106068.2, ENSMUST00000110438.3
    Conserved Domains (1) summary
    cl26593
    Location:319356
    DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    25840795..25973782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159536.1XP_036015429.1  reticulophagy regulator 1 isoform X1

    Conserved Domains (1) summary
    cd22560
    Location:50242
    RETR1_RHD; N-terminal reticulon-homology domain of Reticulophagy regulator 1
  2. XM_036159537.1XP_036015430.1  reticulophagy regulator 1 isoform X3

    Conserved Domains (1) summary
    cl41772
    Location:184
    Arl6IP1_RETR3-like; ADP-ribosylation factor-like protein 6-interacting protein 1, Reticulophagy regulator 3, and similar proteins
  3. XM_006520134.5XP_006520197.1  reticulophagy regulator 1 isoform X2

    See identical proteins and their annotated locations for XP_006520197.1

    UniProtKB/Swiss-Prot
    Q8VE91
    Conserved Domains (1) summary
    cl26593
    Location:319356
    DUF2076; Uncharacterized protein conserved in bacteria (DUF2076)