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SNRPA1 small nuclear ribonucleoprotein polypeptide A' [ Homo sapiens (human) ]

Gene ID: 6627, updated on 5-Sep-2021

Summary

Official Symbol
SNRPA1provided by HGNC
Official Full Name
small nuclear ribonucleoprotein polypeptide A'provided by HGNC
Primary source
HGNC:HGNC:11152
See related
Ensembl:ENSG00000131876 MIM:603521
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Lea1; U2A'
Expression
Ubiquitous expression in bone marrow (RPKM 26.0), testis (RPKM 22.8) and 25 other tissues See more
Orthologs
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Genomic context

See SNRPA1 in Genome Data Viewer
Location:
15q26.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (101281510..101295248, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (101821715..101835453, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984727 Neighboring gene selenoprotein S Neighboring gene uncharacterized LOC100507472 Neighboring gene proprotein convertase subtilisin/kexin type 6 Neighboring gene PCSK6 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of small nuclear ribonucleoprotein polypeptide A' (SNRPA1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev Rev inhibits the binding of U2 small nuclear ribonucleoprotein within the spliceosome PubMed
Tat tat Small nuclear ribonucleoprotein polypeptide A' (SNRPA1) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
tat U2 snRNPs interact with the HIV-1 Tat cofactor TAT-SF1 and stimulate transcription from the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables U2 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing TAS
Traceable Author Statement
more info
PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermatogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of U2-type precatalytic spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of small nuclear ribonucleoprotein complex TAS
Traceable Author Statement
more info
PubMed 
part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
U2 small nuclear ribonucleoprotein A'
Names
U2 small nuclear ribonucleoprotein polypeptide A'
U2 snRNP A'

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003090.4NP_003081.2  U2 small nuclear ribonucleoprotein A'

    See identical proteins and their annotated locations for NP_003081.2

    Status: VALIDATED

    Source sequence(s)
    AC023024, AK312200, BC022816
    Consensus CDS
    CCDS10391.1
    UniProtKB/Swiss-Prot
    P09661
    Related
    ENSP00000254193.6, ENST00000254193.11
    Conserved Domains (2) summary
    sd00031
    Location:2243
    LRR_1; leucine-rich repeat [structural motif]
    pfam14580
    Location:1175
    LRR_9; Leucine-rich repeat

RNA

  1. NR_135506.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC023024, AJ130972, AL538391, BC022816
  2. NR_135507.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AJ130971, AL538391, BC022816
  3. NR_135508.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC023024
    Related
    ENST00000559309.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    101281510..101295248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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