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Eapp E2F-associated phosphoprotein [ Mus musculus (house mouse) ]

Gene ID: 66266, updated on 26-Sep-2022

Summary

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Official Symbol
Eappprovided by MGI
Official Full Name
E2F-associated phosphoproteinprovided by MGI
Primary source
MGI:MGI:1913516
See related
Ensembl:ENSMUSG00000054302 AllianceGenome:MGI:1913516
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810011O16Rik
Summary
Predicted to be involved in positive regulation of cell population proliferation. Predicted to act upstream of or within negative regulation of transcription elongation from RNA polymerase II promoter and positive regulation of transcription elongation from RNA polymerase II promoter. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human EAPP (E2F associated phosphoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.3), placenta adult (RPKM 10.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Eapp in Genome Data Viewer
Location:
12; 12 C1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (54717125..54743245, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (54670340..54695899, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene microRNA 1892 Neighboring gene serine palmitoyltransferase, small subunit A Neighboring gene predicted gene, 40884 Neighboring gene predicted gene, 36262 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene predicted gene, 22513 Neighboring gene ribosomal protein L31, pseudogene 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic expression analysis of E2F-associated phosphoprotein in stress responses in the mouse. Duan C, et al. Gene, 2016 May 1. PMID 26802973
  2. Spatiotemporal Expression of EAPP Modulates Neuronal Apoptosis and Reactive Astrogliosis After Spinal Cord Injury. Chen M, et al. J Cell Biochem, 2015 Jul. PMID 25704466
  3. EAPP, a novel E2F binding protein that modulates E2F-dependent transcription. Novy M, et al. Mol Biol Cell, 2005 May. PMID 15716352, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (16) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
E2F-associated phosphoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331162.1 → NP_001318091.1  E2F-associated phosphoprotein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC165349, AK012800, CT030142
    Consensus CDS
    CCDS88337.1
    UniProtKB/Swiss-Prot
    Q5BU09
    Related
    ENSMUSP00000106341.4, ENSMUST00000110713.10

  2. NM_025456.4 → NP_079732.1  E2F-associated phosphoprotein isoform 1

    See identical proteins and their annotated locations for NP_079732.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC165349, AK007442, CT030142
    Consensus CDS
    CCDS25910.1
    UniProtKB/Swiss-Prot
    Q5BU09, Q9D914
    Related
    ENSMUSP00000123698.2, ENSMUST00000161592.8
    Conserved Domains (1) summary
    pfam10238
    Location:136 → 279
    Eapp_C; E2F-associated phosphoprotein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    54717125..54743245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516142.5 → XP_006516205.1  E2F-associated phosphoprotein isoform X1

    See identical proteins and their annotated locations for XP_006516205.1

    UniProtKB/Swiss-Prot
    Q5BU09, Q9D914
    Conserved Domains (1) summary
    pfam10238
    Location:136 → 279
    Eapp_C; E2F-associated phosphoprotein

  2. XM_030246849.2 → XP_030102709.1  E2F-associated phosphoprotein isoform X2

    Conserved Domains (1) summary
    pfam10238
    Location:72 → 215
    Eapp_C; E2F-associated phosphoprotein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BU09.2 GenPept UniProtKB/Swiss-Prot:Q5BU09

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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