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Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 [ Mus musculus (house mouse) ]

Gene ID: 66259, updated on 5-Mar-2024

Summary

Official Symbol
Camk2n1provided by MGI
Official Full Name
calcium/calmodulin-dependent protein kinase II inhibitor 1provided by MGI
Primary source
MGI:MGI:1913509
See related
Ensembl:ENSMUSG00000046447 AllianceGenome:MGI:1913509
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810006K23Rik
Summary
Enables protein kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of ERK1 and ERK2 cascade; negative regulation of cellular protein metabolic process; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in postsynaptic density. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and stomach. Human ortholog(s) of this gene implicated in ovarian cancer; ovarian carcinoma; and prostate adenocarcinoma. Orthologous to human CAMK2N1 (calcium/calmodulin dependent protein kinase II inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 299.0), frontal lobe adult (RPKM 219.4) and 5 other tissues See more
Orthologs
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Genomic context

See Camk2n1 in Genome Data Viewer
Location:
4 D3; 4 70.3 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138182459..138187437)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138455148..138460126)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L38, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E8003 Neighboring gene STARR-seq mESC enhancer starr_11803 Neighboring gene STARR-seq mESC enhancer starr_11805 Neighboring gene mitochondrial ubiquitin ligase activator of NFKB 1 Neighboring gene STARR-seq mESC enhancer starr_11806 Neighboring gene predicted gene, 32549 Neighboring gene STARR-seq mESC enhancer starr_11810 Neighboring gene von Willebrand factor A domain containing 5B1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-dependent protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase II inhibitor 1
Names
CaMKII inhibitor protein alpha
CaMKIIN-alpha
CaMKIINalpha
calcium/calmodulin-dependent protein kinase II inhibitor alpha
mCaMKIINalpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025451.2NP_079727.1  calcium/calmodulin-dependent protein kinase II inhibitor 1

    See identical proteins and their annotated locations for NP_079727.1

    Status: VALIDATED

    Source sequence(s)
    AL807249
    Consensus CDS
    CCDS38930.1
    UniProtKB/Swiss-Prot
    Q6QWF9
    Related
    ENSMUSP00000060349.4, ENSMUST00000050918.4
    Conserved Domains (1) summary
    pfam15170
    Location:178
    CaM-KIIN; Calcium/calmodulin-dependent protein kinase II inhibitor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    138182459..138187437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)