Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Camk2n1provided by MGI
Official Full Name: calcium/calmodulin-dependent protein kinase II inhibitor 1provided by MGI
Primary source: MGI:MGI:1913509
See related: Ensembl:ENSMUSG00000046447 AllianceGenome:MGI:1913509
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810006K23Rik
Summary: Enables protein kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of ERK1 and ERK2 cascade; negative regulation of cellular protein metabolic process; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in postsynaptic density. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and stomach. Human ortholog(s) of this gene implicated in ovarian cancer; ovarian carcinoma; and prostate adenocarcinoma. Orthologous to human CAMK2N1 (calcium/calmodulin dependent protein kinase II inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 299.0), frontal lobe adult (RPKM 219.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4; 4 D3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (138182459..138187437)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (138455148..138460126)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CAMK2N1 has a cancer-suppressive function in colorectal carcinoma via effects on the Wnt/beta-catenin pathway.
Title: CAMK2N1 has a cancer-suppressive function in colorectal carcinoma via effects on the Wnt/β-catenin pathway.
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Title: Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Camk2n1 down-regulation caused dorsal striatum-related cognitive disorders by inhibiting synaptic plasticity.
Title: Down-regulation of dorsal striatal αCaMKII causes striatum-related cognitive and synaptic disorders.
We propose that the differential regulation of multiple sense and novel overlapping natural antisense transcripts at the Nrgn and Camk2n1 loci will increase the diversity of posttranscriptional regulation
Title: Spatiotemporal regulation of multiple overlapping sense and novel natural antisense transcripts at the Nrgn and Camk2n1 gene loci during mouse cerebral corticogenesis.
The mouse Ca2+/calmodulin kinase II inhibitor alpha (CaMKIINalpha) gene encodes a 2.9kb brain-specific transcript whose expression is downregulated in mouse brain during Japanese encephalitis virus and rabies virus infection.
Title: Regulation of Ca2+/calmodulin kinase II inhibitor alpha (CaMKIINalpha) in virus-infected mouse brain.
Camk2n1 mRNA expression is down regulated in mouse brain during virus infection
Title: Regulation of Ca2+/calmodulin kinase II inhibitor alpha (CaMKIINalpha) in virus-infected mouse brain.
Camk2n1 was shown to be a 37 kDa protein localized in the post synaptic density (PSD) of mouse brain
Title: Characterization of mouse neuronal Ca2+/calmodulin kinase II inhibitor alpha.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

D4Bwg23e (e-PCR), detects polymorphism
- UniSTS:142451

AI891706 (e-PCR)
- UniSTS:179098

AI848599 (e-PCR)
- UniSTS:179101

HSC1IC062 (e-PCR)
- UniSTS:39120

RH129939 (e-PCR)
- UniSTS:213227

Homology

Homologs of the Camk2n1 gene: The Camk2n1 gene is conserved in human, chimpanzee, Rhesus monkey, cow, and rat.
Orthologs from Annotation Pipeline: 315 organisms have orthologs with human gene Camk2n1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-dependent protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables calcium-dependent protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcium/calmodulin-dependent protein kinase II inhibitor 1

Names: CaMKII inhibitor protein alpha; CaMKIIN-alpha; CaMKIINalpha; calcium/calmodulin-dependent protein kinase II inhibitor alpha; mCaMKIINalpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025451.2 → NP_079727.1 calcium/calmodulin-dependent protein kinase II inhibitor 1

See identical proteins and their annotated locations for NP_079727.1

Status: VALIDATED

Source sequence(s)

AL807249

Consensus CDS

CCDS38930.1

UniProtKB/Swiss-Prot

Q6QWF9

UniProtKB/TrEMBL

A0A6P5PM48, A0A8C6H5R7

Related

ENSMUSP00000060349.4, ENSMUST00000050918.4

Conserved Domains (1) summary

pfam15170
Location:1 → 78

CaM-KIIN; Calcium/calmodulin-dependent protein kinase II inhibitor