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Nemf nuclear export mediator factor [ Mus musculus (house mouse) ]

Gene ID: 66244, updated on 9-Sep-2018

Summary

Official Symbol
Nemfprovided by MGI
Official Full Name
nuclear export mediator factorprovided by MGI
Primary source
MGI:MGI:1918305
See related
Ensembl:ENSMUSG00000020982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sdccag1; 1500011I12Rik; 4933405E14Rik
Expression
Broad expression in CNS E11.5 (RPKM 12.6), CNS E14 (RPKM 9.0) and 21 other tissues See more
Orthologs

Genomic context

See Nemf in Genome Data Viewer
Location:
12; 12 C2
Exon count:
33
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (69311543..69357176, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (70412530..70458153, complement)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene polymerase (DNA directed), epsilon 2 (p59 subunit) Neighboring gene kelch domain containing 1 Neighboring gene kelch domain containing 2 Neighboring gene 7S RNA 2 Neighboring gene ribosomal protein S3A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
nuclear export ISO
Inferred from Sequence Orthology
more info
 
rescue of stalled ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosome-associated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
RQC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nuclear export mediator factor Nemf
Names
serologically defined colon cancer antigen 1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025441.3NP_079717.2  nuclear export mediator factor Nemf

    See identical proteins and their annotated locations for NP_079717.2

    Status: VALIDATED

    Source sequence(s)
    AK039497, AK149005, BC039647, BY241581, CB524482
    Consensus CDS
    CCDS25951.1
    UniProtKB/Swiss-Prot
    Q8CCP0
    Related
    ENSMUSP00000021368.8, ENSMUST00000021368.9
    Conserved Domains (4) summary
    COG1293
    Location:1642
    YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]
    pfam05670
    Location:530604
    DUF814; Domain of unknown function (DUF814)
    pfam11923
    Location:9591055
    DUF3441; Domain of unknown function (DUF3441)
    cl22451
    Location:656762
    ASF1_hist_chap; ASF1 like histone chaperone

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

    Range
    69311543..69357176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244157.2XP_011242459.1  nuclear export mediator factor Nemf isoform X1

    Conserved Domains (3) summary
    COG1293
    Location:1642
    YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]
    pfam05670
    Location:530604
    DUF814; Domain of unknown function (DUF814)
    cl22451
    Location:656762
    ASF1_hist_chap; ASF1 like histone chaperone

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181665.1: Suppressed sequence

    Description
    NM_181665.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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