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FSCN1 fascin actin-bundling protein 1 [ Homo sapiens (human) ]

Gene ID: 6624, updated on 4-Dec-2023

Summary

Official Symbol
FSCN1provided by HGNC
Official Full Name
fascin actin-bundling protein 1provided by HGNC
Primary source
HGNC:HGNC:11148
See related
Ensembl:ENSG00000075618 MIM:602689; AllianceGenome:HGNC:11148
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSN; SNL; p55; FAN1
Summary
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
Expression
Broad expression in brain (RPKM 42.7), placenta (RPKM 36.2) and 24 other tissues See more
Orthologs
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Genomic context

See FSCN1 in Genome Data Viewer
Location:
7p22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (5592816..5606655)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (5710346..5724185)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (5632447..5646286)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5567118-5567988 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5567989-5568858 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5568859-5569728 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25595 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25596 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5573209-5574078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5586399-5586898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5593001-5593846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5594693-5595538 Neighboring gene actin beta Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5595539-5596384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25599 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5597701-5598249 Neighboring gene S100 calcium binding protein A11 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5601490-5602016 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5602017-5602541 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5602542-5603067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5609174-5610162 Neighboring gene CRISPRi-validated cis-regulatory element chr7.769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5626381-5626880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17926 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:5633617-5634192 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17928 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:5634770-5635345 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:5636965-5637180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5642390-5643243 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5643244-5644096 Neighboring gene Sharpr-MPRA regulatory region 1133 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5648079-5648632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5655393-5656132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5666829-5667500 Neighboring gene VISTA enhancer hs1623 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:5678992-5679856 Neighboring gene ring finger protein 216 Neighboring gene RNF216 intronic transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25608 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25609 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5735716-5736216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5736217-5736717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25610 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:5741581-5742780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25611 Neighboring gene microRNA 6874

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of fascin actin-bundling protein 1 (FSCN1) in human primary T cells PubMed
Vif vif HIV-1 Vif upregulates the expression of fascin homolog 1, actin-bundling protein (FSCN1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ38511, FLJ43305

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell motility IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell junction assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment of apical/basal cell polarity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microspike assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microspike assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in parallel actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of extracellular matrix disassembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of filopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lamellipodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of podosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of microvillus assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell projection membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell projection membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in filopodium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in growth cone IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in microspike IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
located_in podosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in ruffle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fascin
Names
55 kDa actin-bundling protein
epididymis secretory sperm binding protein
fascin homolog 1, actin-bundling protein
singed-like (fascin homolog, sea urchin)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030004.1 RefSeqGene

    Range
    5012..18851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003088.4NP_003079.1  fascin

    See identical proteins and their annotated locations for NP_003079.1

    Status: REVIEWED

    Source sequence(s)
    AK095254, BC000521
    Consensus CDS
    CCDS5342.1
    UniProtKB/Swiss-Prot
    A6NI89, B2RE97, Q16658, Q96IC5, Q96IH1, Q9BRF1
    UniProtKB/TrEMBL
    A0A384MEG1, B3KTA3
    Related
    ENSP00000371798.3, ENST00000382361.8
    Conserved Domains (2) summary
    cd00257
    Location:383493
    Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
    pfam06268
    Location:268378
    Fascin; Fascin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    5592816..5606655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    5710346..5724185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)