Format

Send to:

Choose Destination

FSCN1 fascin actin-bundling protein 1 [ Homo sapiens (human) ]

Gene ID: 6624, updated on 28-Oct-2018

Summary

Official Symbol
FSCN1provided by HGNC
Official Full Name
fascin actin-bundling protein 1provided by HGNC
Primary source
HGNC:HGNC:11148
See related
Ensembl:ENSG00000075618 MIM:602689; Vega:OTTHUMG00000090599
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSN; SNL; p55; FAN1
Summary
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
Expression
Broad expression in brain (RPKM 42.7), placenta (RPKM 36.2) and 24 other tissues See more
Orthologs

Genomic context

See FSCN1 in Genome Data Viewer
Location:
7p22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (5592805..5606656)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (5632436..5646287)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene actin beta Neighboring gene S100 calcium binding protein A11 pseudogene Neighboring gene uncharacterized LOC107986762 Neighboring gene VISTA enhancer hs1623 Neighboring gene ring finger protein 216 Neighboring gene RNF216 intronic transcript 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of fascin actin-bundling protein 1 (FSCN1) in human primary T cells PubMed
Vif vif HIV-1 Vif upregulates the expression of fascin homolog 1, actin-bundling protein (FSCN1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interleukin-4 and 13 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-4 and 13 signaling, organism-specific biosystemInterleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38511, FLJ43305

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
cadherin binding HDA PubMed 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell motility IDA
Inferred from Direct Assay
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cell-cell junction assembly IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
establishment of apical/basal cell polarity IDA
Inferred from Direct Assay
more info
PubMed 
establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microspike assembly IDA
Inferred from Direct Assay
more info
PubMed 
microspike assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extracellular matrix disassembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of filopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of lamellipodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of podosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of microvillus assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cell projection membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell projection membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
filopodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
filopodium IDA
Inferred from Direct Assay
more info
PubMed 
growth cone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
invadopodium IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
microspike IDA
Inferred from Direct Assay
more info
PubMed 
microvillus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microvillus IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
podosome IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fascin
Names
55 kDa actin-bundling protein
epididymis secretory sperm binding protein
fascin homolog 1, actin-bundling protein
singed-like (fascin homolog, sea urchin)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030004.1 RefSeqGene

    Range
    5001..18852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003088.3NP_003079.1  fascin

    See identical proteins and their annotated locations for NP_003079.1

    Status: REVIEWED

    Source sequence(s)
    AK095254, BC000521, BI546742, BU629782
    Consensus CDS
    CCDS5342.1
    UniProtKB/Swiss-Prot
    Q16658
    UniProtKB/TrEMBL
    B3KTA3
    Related
    ENSP00000371798.3, OTTHUMP00000115718, ENST00000382361.7, OTTHUMT00000207153
    Conserved Domains (2) summary
    cd00257
    Location:383493
    Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
    pfam06268
    Location:268378
    Fascin; Fascin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    5592805..5606656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center