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Atp6v1g2 ATPase, H+ transporting, lysosomal V1 subunit G2 [ Mus musculus (house mouse) ]

Gene ID: 66237, updated on 8-Dec-2022

Summary

Official Symbol
Atp6v1g2provided by MGI
Official Full Name
ATPase, H+ transporting, lysosomal V1 subunit G2provided by MGI
Primary source
MGI:MGI:1913487
See related
Ensembl:ENSMUSG00000024403 AllianceGenome:MGI:1913487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NG38; VAG2; Atp6g2; 1500002D01Rik
Summary
Enables ATP hydrolysis activity and proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to act upstream of or within ion transport. Is integral component of synaptic vesicle membrane. Part of vacuolar proton-transporting V-type ATPase complex. Is expressed in several structures, including nervous system. Orthologous to human ATP6V1G2 (ATPase H+ transporting V1 subunit G2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 155.4), frontal lobe adult (RPKM 143.5) and 6 other tissues See more
Orthologs
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Genomic context

See Atp6v1g2 in Genome Data Viewer
Location:
17; 17 B1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35453910..35457743)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35234931..35238767)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor Neighboring gene microRNA 6974 Neighboring gene lymphotoxin A Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1 Neighboring gene DEAD box helicase 39b Neighboring gene predicted gene, 22589 Neighboring gene microRNA 6975

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables proton-transporting ATPase activity, rotational mechanism IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in extrinsic component of synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of vacuolar proton-transporting V-type ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of vacuolar proton-transporting V-type ATPase complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
V-type proton ATPase subunit G 2
Names
ATPase, H+ transporting, V1 subunit G
ATPase, H+ transporting, lysosomal (vacuolar proton pump)
ATPase, H+ transporting, lysosomal 13kD, V1 subunit G
V-ATPase 13 kDa subunit 2
V-ATPase subunit G 2
lysosomal 13kDa
vacuolar proton pump subunit G 2
NP_001334280.1
NP_075668.1
XP_006524858.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347351.1NP_001334280.1  V-type proton ATPase subunit G 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC020190, CR974444
    Consensus CDS
    CCDS84301.1
    UniProtKB/Swiss-Prot
    Q9WTT4
    UniProtKB/TrEMBL
    G5E923
    Related
    ENSMUSP00000134733.2, ENSMUST00000130992.2
    Conserved Domains (1) summary
    cl03922
    Location:166
    V-ATPase_G; Vacuolar (H+)-ATPase G subunit
  2. NM_023179.3NP_075668.1  V-type proton ATPase subunit G 2 isoform 1

    See identical proteins and their annotated locations for NP_075668.1

    Status: VALIDATED

    Source sequence(s)
    BC020190, BU558667
    Consensus CDS
    CCDS37597.1
    UniProtKB/Swiss-Prot
    Q9WTT4
    UniProtKB/TrEMBL
    A0A6P5RCW9, A0A8C6MQU1, Q54A87
    Related
    ENSMUSP00000069482.9, ENSMUST00000068261.9
    Conserved Domains (1) summary
    pfam03179
    Location:3107
    V-ATPase_G; Vacuolar (H+)-ATPase G subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35453910..35457743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524795.4XP_006524858.1  V-type proton ATPase subunit G 2 isoform X1

    See identical proteins and their annotated locations for XP_006524858.1

    UniProtKB/TrEMBL
    G5E923
    Conserved Domains (1) summary
    cl03922
    Location:166
    V-ATPase_G; Vacuolar (H+)-ATPase G subunit