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Msmo1 methylsterol monoxygenase 1 [ Mus musculus (house mouse) ]

Gene ID: 66234, updated on 5-Jan-2023

Summary

Official Symbol
Msmo1provided by MGI
Official Full Name
methylsterol monoxygenase 1provided by MGI
Primary source
MGI:MGI:1913484
See related
Ensembl:ENSMUSG00000031604 AllianceGenome:MGI:1913484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DESP4; ERG25; Sc4mol; 1500001G16Rik
Summary
Predicted to enable C-4 methylsterol oxidase activity. Predicted to be involved in sterol biosynthetic process. Predicted to act upstream of or within cholesterol biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MSMO1 (methylsterol monooxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 43.9), CNS E18 (RPKM 39.0) and 23 other tissues See more
Orthologs
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Genomic context

See Msmo1 in Genome Data Viewer
Location:
8; 8 B3.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (65171157..65186822, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (64718123..64733578, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene microRNA 710 Neighboring gene carboxypeptidase E Neighboring gene kelch-like 2, Mayven Neighboring gene predicted gene, 46040 Neighboring gene predicted gene, 53437

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-4 methylsterol oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
methylsterol monooxygenase 1
Names
C-4 methylsterol oxidase
sterol-C4-methyl oxidase
sterol-C4-methyl oxidase-like
NP_079712.1
XP_036010125.1
XP_036010126.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025436.3NP_079712.1  methylsterol monooxygenase 1

    See identical proteins and their annotated locations for NP_079712.1

    Status: VALIDATED

    Source sequence(s)
    AC152168, AK005090
    Consensus CDS
    CCDS22328.1
    UniProtKB/Swiss-Prot
    Q543V8, Q9CRA4
    Related
    ENSMUSP00000034015.5, ENSMUST00000034015.11
    Conserved Domains (1) summary
    pfam04116
    Location:143274
    FA_hydroxylase; Fatty acid hydroxylase superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    65171157..65186822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154232.1XP_036010125.1  methylsterol monooxygenase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q543V8
    Conserved Domains (1) summary
    pfam04116
    Location:143274
    FA_hydroxylase; Fatty acid hydroxylase superfamily
  2. XM_036154233.1XP_036010126.1  methylsterol monooxygenase 1 isoform X2