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Thoc7 THO complex 7 [ Mus musculus (house mouse) ]

Gene ID: 66231, updated on 26-Sep-2022

Summary

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Official Symbol
Thoc7provided by MGI
Official Full Name
THO complex 7provided by MGI
Primary source
MGI:MGI:1913481
See related
Ensembl:ENSMUSG00000053453 AllianceGenome:MGI:1913481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nif3l1bp1
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA export from nucleus and viral mRNA export from host cell nucleus. Predicted to act upstream of or within RNA splicing and mRNA transport. Predicted to be located in cytosol and nuclear speck. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Is expressed in inferior colliculus; midbrain ventricular layer; submandibular gland primordium; telencephalon ventricular layer; and vibrissa. Orthologous to human THOC7 (THO complex 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 25.3), CNS E14 (RPKM 20.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Thoc7 in Genome Data Viewer
Location:
14; 14 A1
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (8507911..8520751)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (13949012..13961995, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 Neighboring gene ataxin 7 Neighboring gene predicted gene, 53821 Neighboring gene predicted gene 11100 Neighboring gene cadherin related family member 18 Neighboring gene zinc finger, AN1-type domain 5 pseudogene Neighboring gene predicted gene, 25964

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Murine leukemia virus uses TREX components for efficient nuclear export of unspliced viral transcripts. Sakuma T, et al. Viruses, 2014 Mar 10. PMID 24618812, Free PMC Article
  2. Identification and characterization of NIF3L1 BP1, a novel cytoplasmic interaction partner of the NIF3L1 protein. Tascou S, et al. Biochem Biophys Res Commun, 2003 Sep 19. PMID 12951069
  3. The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming. Wang L, et al. Cell Stem Cell, 2013 Dec 5. PMID 24315442, Free PMC Article
  4. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

See all (19) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results imply that murine leukemia virus requires UAP56, THOC5 and THOC7, in addition to NXF1, for nuclear export of viral transcripts.
    Title: Murine leukemia virus uses TREX components for efficient nuclear export of unspliced viral transcripts.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC151296, MGC151322, 1500006O09Rik, 9230101K24Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in viral mRNA export from host cell nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of THO complex ISO
Inferred from Sequence Orthology
more info
  
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of THO complex part of transcription export complex ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription export complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
THO complex subunit 7 homolog
Names
THO complex 7 homolog
ngg1-interacting factor 3-like protein 1-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285780.1 → NP_001272709.1  THO complex subunit 7 homolog isoform 3

    See identical proteins and their annotated locations for NP_001272709.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK147003, CF949442, CK329337
    UniProtKB/Swiss-Prot
    Q7TMY4
    Related
    ENSMUST00000225401.2
    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  2. NM_001359900.1 → NP_001346829.1  THO complex subunit 7 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC171681, AK147003, CF949442, CK329337
    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  3. NM_001359901.1 → NP_001346830.1  THO complex subunit 7 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC116479, AK005176, CF949442
    Consensus CDS
    CCDS88568.1
    UniProtKB/TrEMBL
    A0A286YCS0
    Related
    ENSMUSP00000153123.2, ENSMUST00000225325.2
    Conserved Domains (2) summary
    pfam05615
    Location:3 → 135
    THOC7; Tho complex subunit 7
    cl25732
    Location:78 → 195
    SMC_N; RecF/RecN/SMC N terminal domain

  4. NM_025435.3 → NP_079711.1  THO complex subunit 7 homolog isoform 1

    See identical proteins and their annotated locations for NP_079711.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK005176, CF949442, CK329337
    Consensus CDS
    CCDS49403.1
    UniProtKB/Swiss-Prot
    Q7TMY4, Q9CQ50
    UniProtKB/TrEMBL
    A0A8C6H5D1
    Related
    ENSMUSP00000065819.9, ENSMUST00000065865.10
    Conserved Domains (1) summary
    pfam05615
    Location:7 → 139
    THOC7; Tho complex subunit 7

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    8507911..8520751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316120.3 → XP_017171609.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  2. XM_011244769.4 → XP_011243071.1  THO complex subunit 7 homolog isoform X2

    See identical proteins and their annotated locations for XP_011243071.1

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  3. XM_006518078.5 → XP_006518141.1  THO complex subunit 7 homolog isoform X2

    See identical proteins and their annotated locations for XP_006518141.1

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  4. XM_030247923.2 → XP_030103783.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  5. XM_030247929.2 → XP_030103789.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  6. XM_006518076.5 → XP_006518139.1  THO complex subunit 7 homolog isoform X1

    Conserved Domains (2) summary
    TIGR02169
    Location:141 → 258
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam05615
    Location:66 → 198
    THOC7; Tho complex subunit 7

  7. XM_030247924.1 → XP_030103784.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  8. XM_036158791.1 → XP_036014684.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  9. XM_036158785.1 → XP_036014678.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  10. XM_030247928.1 → XP_030103788.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  11. XM_036158788.1 → XP_036014681.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  12. XM_036158789.1 → XP_036014682.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  13. XM_030247926.1 → XP_030103786.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  14. XM_036158786.1 → XP_036014679.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  15. XM_036158784.1 → XP_036014677.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  16. XM_036158790.1 → XP_036014683.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  17. XM_036158787.1 → XP_036014680.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  18. XM_030247925.1 → XP_030103785.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  19. XM_030247927.1 → XP_030103787.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

  20. XM_030247931.2 → XP_030103791.1  THO complex subunit 7 homolog isoform X2

    Conserved Domains (1) summary
    pfam05615
    Location:1 → 87
    THOC7; Tho complex subunit 7

RNA

  1. XR_003950880.2 RNA Sequence

  2. XR_382964.4 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013578.1: Suppressed sequence

    Description
    NM_001013578.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TMY4.2 GenPept UniProtKB/Swiss-Prot:Q7TMY4

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