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Pithd1 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 66193, updated on 5-Mar-2024

Summary

Official Symbol
Pithd1provided by MGI
Official Full Name
PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1provided by MGI
Primary source
MGI:MGI:1913443
See related
Ensembl:ENSMUSG00000028669 AllianceGenome:MGI:1913443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trp26; 1110049F12Rik
Summary
Involved in positive regulation of megakaryocyte differentiation. Acts upstream of or within regulation of proteasomal protein catabolic process; single fertilization; and spermatid development. Located in sperm cytoplasmic droplet. Is expressed in several structures, including alimentary system; central nervous system; ganglia; nose; and respiratory system. Orthologous to human PITHD1 (PITH domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 52.8), colon adult (RPKM 47.2) and 28 other tissues See more
Orthologs
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Genomic context

Location:
4 D3; 4 68.34 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135702913..135714555, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135975602..135987244, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3529 Neighboring gene galactose-4-epimerase, UDP Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135528566-135528675 Neighboring gene lysophospholipase 2 Neighboring gene predicted gene 13007 Neighboring gene elongin A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

General protein information

Preferred Names
PITH domain-containing protein 1
Names
AD039
thioredoxin family Trp26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025411.4NP_079687.3  PITH domain-containing protein 1

    See identical proteins and their annotated locations for NP_079687.3

    Status: VALIDATED

    Source sequence(s)
    BC052695, BY044314
    Consensus CDS
    CCDS51330.1
    UniProtKB/Swiss-Prot
    Q8BMZ1, Q8BWR2
    Related
    ENSMUSP00000101477.3, ENSMUST00000105851.9
    Conserved Domains (1) summary
    pfam06201
    Location:35175
    PITH; PITH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135702913..135714555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)