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Sptssb serine palmitoyltransferase, small subunit B [ Mus musculus (house mouse) ]

Gene ID: 66183, updated on 19-Apr-2019

Summary

Official Symbol
Sptssbprovided by MGI
Official Full Name
serine palmitoyltransferase, small subunit Bprovided by MGI
Primary source
MGI:MGI:1913433
See related
Ensembl:ENSMUSG00000043461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADMP; Sssptb; 1110032A04Rik
Expression
Biased expression in bladder adult (RPKM 217.4) and stomach adult (RPKM 59.8) See more
Orthologs

Genomic context

See Sptssb in Genome Data Viewer
Location:
3; 3 E2
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (69819538..69859894, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (69623460..69663818, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene NMD3 ribosome export adaptor Neighboring gene ribosome production factor 2 homolog pseudogene Neighboring gene predicted gene, 35817 Neighboring gene nucleophosmin 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Targeted (2) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to serine C-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to serine C-palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to serine C-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ceramide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of serine C-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of serine C-palmitoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
serine C-palmitoyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine C-palmitoyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
serine C-palmitoyltransferase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine palmitoyltransferase small subunit B
Names
androgen down regulated in mouse prostate
small subunit of serine palmitoyltransferase B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164210.2NP_001157682.1  serine palmitoyltransferase small subunit B isoform a

    See identical proteins and their annotated locations for NP_001157682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AC122009, AK004017, AK009973, BC022628
    Consensus CDS
    CCDS38453.1
    UniProtKB/Swiss-Prot
    Q925E8
    Related
    ENSMUSP00000131241.1, ENSMUST00000171529.3
    Conserved Domains (1) summary
    pfam11779
    Location:759
    DUF3317; Protein of unknown function (DUF3317)
  2. NM_001286959.1NP_001273888.1  serine palmitoyltransferase small subunit B isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has a different 3' structure which results in a frameshift compared to variant 1. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC122009
    Conserved Domains (1) summary
    pfam11779
    Location:757
    DUF3317; Protein of unknown function (DUF3317)
  3. NM_133675.3NP_598436.1  serine palmitoyltransferase small subunit B isoform a

    See identical proteins and their annotated locations for NP_598436.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AC122009, AK004017, BC022628
    Consensus CDS
    CCDS38453.1
    UniProtKB/Swiss-Prot
    Q925E8
    Related
    ENSMUSP00000062794.7, ENSMUST00000051239.12
    Conserved Domains (1) summary
    pfam11779
    Location:759
    DUF3317; Protein of unknown function (DUF3317)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    69819538..69859894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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