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Nop10 NOP10 ribonucleoprotein [ Mus musculus (house mouse) ]

Gene ID: 66181, updated on 12-May-2024

Summary

Official Symbol
Nop10provided by MGI
Official Full Name
NOP10 ribonucleoproteinprovided by MGI
Primary source
MGI:MGI:1913431
See related
Ensembl:ENSMUSG00000027133 AllianceGenome:MGI:1913431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nola3; NOP10P; 1110036B12Rik
Summary
Predicted to enable box H/ACA snoRNA binding activity and telomerase RNA binding activity. Predicted to be involved in snRNA pseudouridine synthesis; snoRNA guided rRNA pseudouridine synthesis; and telomere maintenance via telomerase. Predicted to act upstream of or within rRNA processing. Predicted to be located in nuclear body. Predicted to be part of box H/ACA snoRNP complex and box H/ACA telomerase RNP complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 1. Orthologous to human NOP10 (NOP10 ribonucleoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 87.2), liver E14.5 (RPKM 82.7) and 28 other tissues See more
Orthologs
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Genomic context

See Nop10 in Genome Data Viewer
Location:
2 E3; 2 56.99 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (112092271..112093243)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (112261926..112262898)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 52523 Neighboring gene lysophosphatidylcholine acyltransferase 4 Neighboring gene STARR-positive B cell enhancer ABC_E4485 Neighboring gene NUT midline carcinoma, family member 1 Neighboring gene STARR-positive B cell enhancer ABC_E7845 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:112106464-112106665 Neighboring gene STARR-positive B cell enhancer ABC_E10129 Neighboring gene solute carrier family 12, member 6 Neighboring gene predicted gene, 39908 Neighboring gene STARR-positive B cell enhancer mm9_chr2:112219168-112219469 Neighboring gene ER membrane protein complex subunit 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables box H/ACA snoRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables snoRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables telomerase RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables telomerase RNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in snRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in snoRNA guided rRNA pseudouridine synthesis ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance via telomerase NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of box H/ACA snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of box H/ACA snoRNP complex ISO
Inferred from Sequence Orthology
more info
 
part_of box H/ACA telomerase RNP complex ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
part_of telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
part_of telomerase holoenzyme complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
H/ACA ribonucleoprotein complex subunit 3
Names
H/ACA small nucleolar RNPs
NOP10 ribonucleoprotein homolog
nucleolar protein 10
nucleolar protein family A, member 3
snoRNP protein NOP10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025403.4NP_079679.1  H/ACA ribonucleoprotein complex subunit 3

    See identical proteins and their annotated locations for NP_079679.1

    Status: VALIDATED

    Source sequence(s)
    AK004120, AK012875
    Consensus CDS
    CCDS38198.1
    UniProtKB/Swiss-Prot
    Q9CQS2
    Related
    ENSMUSP00000028553.4, ENSMUST00000028553.4
    Conserved Domains (1) summary
    pfam04135
    Location:452
    Nop10p; Nucleolar RNA-binding protein, Nop10p family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    112092271..112093243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)