U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

P3h4 prolyl 3-hydroxylase family member 4 (non-enzymatic) [ Mus musculus (house mouse) ]

Gene ID: 66180, updated on 26-Sep-2022

Summary

Official Symbol
P3h4provided by MGI
Official Full Name
prolyl 3-hydroxylase family member 4 (non-enzymatic)provided by MGI
Primary source
MGI:MGI:1913430
See related
Ensembl:ENSMUSG00000006931 AllianceGenome:MGI:1913430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sc65; Leprel4; 1110036O03Rik
Summary
Predicted to contribute to collagen binding activity. Involved in several processes, including collagen biosynthetic process; collagen fibril organization; and peptidyl-lysine hydroxylation. Part of catalytic complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Orthologous to human P3H4 (prolyl 3-hydroxylase family member 4 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 131.7), adrenal adult (RPKM 53.0) and 16 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See P3h4 in Genome Data Viewer
Location:
11; 11 D
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100299293..100305542, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100408467..100414716, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene junction plakoglobin Neighboring gene predicted gene 12348 Neighboring gene FK506 binding protein 10 Neighboring gene 5'-nucleotidase, cytosolic IIIB Neighboring gene kelch-like 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to collagen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in bone remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in collagen fibril organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in collagen fibril organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-lysine hydroxylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-lysine hydroxylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of catalytic complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in synaptonemal complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
endoplasmic reticulum protein SC65
Names
SC65 synaptonemal complex protein (Sc65-pending)
leprecan-like 4
leprecan-like protein 4
synaptonemal complex protein SC65

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378981.1NP_001365910.1  endoplasmic reticulum protein SC65 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL590968
  2. NM_176830.3NP_789800.1  endoplasmic reticulum protein SC65 isoform 2 precursor

    See identical proteins and their annotated locations for NP_789800.1

    Status: VALIDATED

    Source sequence(s)
    AL590968
    Consensus CDS
    CCDS25421.1
    UniProtKB/Swiss-Prot
    Q8K2B0
    Related
    ENSMUSP00000065278.7, ENSMUST00000066489.13

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100299293..100305542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)