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SNAPC2 small nuclear RNA activating complex polypeptide 2 [ Homo sapiens (human) ]

Gene ID: 6618, updated on 1-Jun-2020

Summary

Official Symbol
SNAPC2provided by HGNC
Official Full Name
small nuclear RNA activating complex polypeptide 2provided by HGNC
Primary source
HGNC:HGNC:11135
See related
Ensembl:ENSG00000104976 MIM:605076
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNAP45; PTFDELTA
Summary
This gene encodes a subunit of the snRNA-activating protein complex which is associated with the TATA box-binding protein. The encoded protein is necessary for RNA polymerase II and III dependent small-nuclear RNA gene transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Expression
Ubiquitous expression in endometrium (RPKM 11.0), testis (RPKM 10.8) and 25 other tissues See more
Orthologs

Genomic context

See SNAPC2 in Genome Data Viewer
Location:
19p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (7920338..7923250)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7985194..7988136)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 7 Neighboring gene transforming growth factor beta receptor 3 like Neighboring gene cortexin 1 Neighboring gene translocase of inner mitochondrial membrane 44

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
snRNA transcription TAS
Traceable Author Statement
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
transcription by RNA polymerase III TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
snRNA-activating protein complex subunit 2
Names
PSE-binding factor subunit delta
PTF subunit delta
SNAPC 45 kDa subunit
SNAPc subunit 2
proximal sequence element-binding transcription factor subunit delta
small nuclear RNA activating complex, polypeptide 2, 45kD
small nuclear RNA activating complex, polypeptide 2, 45kDa
snRNA-activating protein complex 45 kDa subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003083.4NP_003074.1  snRNA-activating protein complex subunit 2

    See identical proteins and their annotated locations for NP_003074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AC010336, U44755
    Consensus CDS
    CCDS12190.1
    UniProtKB/Swiss-Prot
    Q13487
    Related
    ENSP00000221573.5, ENST00000221573.11
    Conserved Domains (1) summary
    pfam11035
    Location:1330
    SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb

RNA

  1. NR_030717.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon compared to variant 1. This variant is represented as non-coding due to uncertainty about its protein-coding capacity. This transcript lacks a portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    BX647416
    Related
    ENST00000597584.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    7920338..7923250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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