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Ifitm3 interferon induced transmembrane protein 3 [ Mus musculus (house mouse) ]

Gene ID: 66141, updated on 12-May-2024

Summary

Official Symbol
Ifitm3provided by MGI
Official Full Name
interferon induced transmembrane protein 3provided by MGI
Primary source
MGI:MGI:1913391
See related
Ensembl:ENSMUSG00000025492 AllianceGenome:MGI:1913391
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fgls; IP15; Cd225; mil-1; Cdw217; DSPA2b; 1110004C05Rik
Summary
Involved in negative regulation of viral entry into host cell and response to virus. Acts upstream of or within defense response to other organism; negative regulation of cell population proliferation; and receptor-mediated endocytosis. Located in several cellular components, including apical part of cell; cell surface; and endoplasmic reticulum. Is expressed in several structures, including alimentary system; egg cylinder; embryo ectoderm; genitourinary system; and mesenchyme derived from lateral plate. Human ortholog(s) of this gene implicated in COVID-19; adenosquamous gallbladder carcinoma; and gallbladder adenocarcinoma. Orthologous to several human genes including IFITM3 (interferon induced transmembrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 350.2), subcutaneous fat pad adult (RPKM 292.7) and 19 other tissues See more
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Genomic context

See Ifitm3 in Genome Data Viewer
Location:
7 F5; 7 86.25 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140589503..140590657, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141009590..141010744, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7514 Neighboring gene predicted gene, 33504 Neighboring gene STARR-seq mESC enhancer starr_20469 Neighboring gene interferon induced transmembrane protein 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:148234260-148234369 Neighboring gene predicted gene, 39114

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to virus ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to interferon-alpha IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
 
involved_in response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to interferon-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
involved_in response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
interferon-induced transmembrane protein 3
Names
dispanin subfamily A member 2b
fragilis protein
ifitm-like protein 1
interferon-inducible protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025378.2NP_079654.1  interferon-induced transmembrane protein 3

    See identical proteins and their annotated locations for NP_079654.1

    Status: PROVISIONAL

    Source sequence(s)
    AK003407
    Consensus CDS
    CCDS21996.1
    UniProtKB/Swiss-Prot
    Q9CQW9, Q9D8L6
    Related
    ENSMUSP00000026565.7, ENSMUST00000026565.7
    Conserved Domains (1) summary
    pfam04505
    Location:45117
    CD225; Interferon-induced transmembrane protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140589503..140590657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)