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SUMO2 small ubiquitin like modifier 2 [ Homo sapiens (human) ]

Gene ID: 6613, updated on 6-May-2021

Summary

Official Symbol
SUMO2provided by HGNC
Official Full Name
small ubiquitin like modifier 2provided by HGNC
Primary source
HGNC:HGNC:11125
See related
Ensembl:ENSG00000188612 MIM:603042
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSMT3; SMT3B; SUMO3; Smt3A; SMT3H2
Summary
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 121.8), lymph node (RPKM 108.7) and 25 other tissues See more
Orthologs
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Genomic context

See SUMO2 in Genome Data Viewer
Location:
17q25.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (75165586..75182959, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73161681..73179054, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 7 Neighboring gene uncharacterized LOC107985034 Neighboring gene 5', 3'-nucleotidase, cytosolic Neighboring gene Jupiter microtubule associated homolog 1 Neighboring gene nucleoporin 85 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene mitochondrial ribosomal protein S7 Neighboring gene MIF4G domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of SMT3 suppressor of mif two 3 homolog 2 (SUMO2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol SUMOylation of HIV-1 IN at positions K46, K136, and K244 by SUMO involves HIV-1 infectivity PubMed
gag-pol HIV-1 IN interacts with SUMO1/SUMO2 and Ubc9 in cells. Upregulations of SUMO1/SUMO2 and Ubc9 inhibit HIV-1 integration, while downregulations of SUMO1/SUMO2 and Ubc9 increase HIV-1 integration PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117191

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables SUMO transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tag IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-like protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in PML body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
small ubiquitin-related modifier 2
Names
SMT3 homolog 2
SMT3 suppressor of mif two 3 homolog 2
sentrin 2
ubiquitin-like protein SMT3A
ubiquitin-like protein SMT3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005849.2NP_001005849.1  small ubiquitin-related modifier 2 isoform b precursor

    See identical proteins and their annotated locations for NP_001005849.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (b), compared to isoform a. The amino acid sequence of isoform b is predicted and has not been experimentally verified.
    Source sequence(s)
    AC022211, BC008450, BF700114
    Consensus CDS
    CCDS45773.1
    UniProtKB/Swiss-Prot
    P61956
    Related
    ENSP00000400886.2, ENST00000314523.7
    Conserved Domains (1) summary
    cl28922
    Location:1764
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  2. NM_006937.4NP_008868.3  small ubiquitin-related modifier 2 isoform a precursor

    See identical proteins and their annotated locations for NP_008868.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC022211, AK024823, BC008450
    Consensus CDS
    CCDS45774.1
    UniProtKB/Swiss-Prot
    P61956
    UniProtKB/TrEMBL
    A0A024R8S3
    Related
    ENSP00000405965.2, ENST00000420826.7
    Conserved Domains (1) summary
    cd16115
    Location:1788
    Ubl_SUMO2_3_4; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier SUMO-2, SUMO-3, SUMO-4, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    75165586..75182959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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