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SUMO3 small ubiquitin like modifier 3 [ Homo sapiens (human) ]

Gene ID: 6612, updated on 7-Jun-2020

Summary

Official Symbol
SUMO3provided by HGNC
Official Full Name
small ubiquitin like modifier 3provided by HGNC
Primary source
HGNC:HGNC:11124
See related
Ensembl:ENSG00000184900 MIM:602231
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMT3A; Smt3B; SMT3H1; SUMO-3
Summary
This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in brain (RPKM 42.6), bone marrow (RPKM 40.3) and 25 other tissues See more
Orthologs

Genomic context

See SUMO3 in Genome Data Viewer
Location:
21q22.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (44805617..44818129, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (46225532..46238044, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 G2 Neighboring gene long intergenic non-protein coding RNA 1424 Neighboring gene PTTG1 interacting protein Neighboring gene integrin subunit beta 2 Neighboring gene uncharacterized LOC107987303

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat downregulates the abundance of SMT3 suppressor of mif two 3 homolog 3 (SUMO3) in the nucleoli of Jurkat T-cells PubMed
integrase gag-pol SUMOylation of HIV-1 IN at positions K46, K136, and K244 by SUMO involves HIV-1 infectivity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tag IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-like protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
kinetochore TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
small ubiquitin-related modifier 3
Names
SMT3 suppressor of mif two 3 homolog 1
SMT3 suppressor of mif two 3 homolog 3
ubiquitin-like protein SMT3B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033969.1 RefSeqGene

    Range
    5001..17513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001286416.1NP_001273345.1  small ubiquitin-related modifier 3 isoform 2

    See identical proteins and their annotated locations for NP_001273345.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site compared to variant 1. The resulting longer isoform (2) has an internal protein segment not found in isoform 1.
    Source sequence(s)
    AK300822, BC000036, BC008420
    Consensus CDS
    CCDS68220.1
    UniProtKB/Swiss-Prot
    P55854
    Related
    ENSP00000409666.2, ENST00000411651.6
    Conserved Domains (2) summary
    cd01763
    Location:7130
    Sumo; Small ubiquitin-related modifier (SUMO)
    smart00213
    Location:17123
    UBQ; Ubiquitin homologues
  2. NM_006936.3NP_008867.2  small ubiquitin-related modifier 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_008867.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the shorter isoform (1).
    Source sequence(s)
    BC000036, BC008420
    Consensus CDS
    CCDS33587.1
    UniProtKB/Swiss-Prot
    P55854
    Related
    ENSP00000330343.6, ENST00000332859.10
    Conserved Domains (1) summary
    cd01763
    Location:792
    Sumo; Small ubiquitin-related modifier (SUMO)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    44805617..44818129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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