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Ppih peptidyl prolyl isomerase H [ Mus musculus (house mouse) ]

Gene ID: 66101, updated on 12-May-2024

Summary

Official Symbol
Ppihprovided by MGI
Official Full Name
peptidyl prolyl isomerase Hprovided by MGI
Primary source
MGI:MGI:106499
See related
Ensembl:ENSMUSG00000060288 AllianceGenome:MGI:106499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CYPH; CYP-20; D4Wsu43e; 1100001J08Rik; 2010111B15Rik; 4833408F11Rik
Summary
Predicted to enable cyclosporin A binding activity; peptidyl-prolyl cis-trans isomerase activity; and ribonucleoprotein complex binding activity. Predicted to be involved in positive regulation of viral genome replication; protein folding; and protein peptidyl-prolyl isomerization. Predicted to be located in nuclear speck. Predicted to be part of U4/U6 snRNP and U4/U6 x U5 tri-snRNP complex. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including central nervous system; extraembryonic component; and retina. Orthologous to human PPIH (peptidylprolyl isomerase H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 13.0), liver E14 (RPKM 10.6) and 22 other tissues See more
Orthologs
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Genomic context

See Ppih in Genome Data Viewer
Location:
4 D2.1; 4 55.34 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (119157207..119177720, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (119300010..119320523, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12927 Neighboring gene claudin 19 Neighboring gene STARR-positive B cell enhancer ABC_E1652 Neighboring gene Y box protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10252 Neighboring gene coiled-coil domain containing 30 Neighboring gene lactate dehydrogenase A, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_11233 Neighboring gene phosphopantothenoylcysteine synthetase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclosporin A binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein peptidyl-prolyl isomerization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of U4/U6 snRNP ISO
Inferred from Sequence Orthology
more info
 
part_of U4/U6 x U5 tri-snRNP complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase H
Names
PPIase H
cyclophilin H
rotamase H
NP_001103599.1
NP_001103600.1
NP_082953.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110129.1NP_001103599.1  peptidyl-prolyl cis-trans isomerase H isoform 1

    See identical proteins and their annotated locations for NP_001103599.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different 3' terminal non-coding exon compared to transcript variant 1. Transcript variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK136330, AK164299, CJ071503
    Consensus CDS
    CCDS18580.1
    UniProtKB/TrEMBL
    Q3UWH9, Q4G0C5
    Related
    ENSMUSP00000101928.3, ENSMUST00000106321.9
    Conserved Domains (1) summary
    cl00197
    Location:8177
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
  2. NM_001110130.1NP_001103600.1  peptidyl-prolyl cis-trans isomerase H isoform 2

    See identical proteins and their annotated locations for NP_001103600.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a different 3' terminal exon compared to transcript variant 1, resulting in a longer isoform (2) with a different C-terminus compared to isoform 1.
    Source sequence(s)
    AK008394, BY708305, CJ071503
    Consensus CDS
    CCDS51288.1
    UniProtKB/Swiss-Prot
    Q9CQU7, Q9D868
    UniProtKB/TrEMBL
    Q3UWH9, Q3UY37
    Related
    ENSMUSP00000101924.2, ENSMUST00000106317.2
    Conserved Domains (1) summary
    cd01926
    Location:11155
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
  3. NM_028677.4NP_082953.1  peptidyl-prolyl cis-trans isomerase H isoform 1

    See identical proteins and their annotated locations for NP_082953.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the most predominant transcript. Transcript variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK003179, BC050116, CJ071503
    Consensus CDS
    CCDS18580.1
    UniProtKB/TrEMBL
    Q3UWH9, Q4G0C5
    Related
    ENSMUSP00000101925.2, ENSMUST00000106318.8
    Conserved Domains (1) summary
    cl00197
    Location:8177
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    119157207..119177720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)