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Lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 [ Mus musculus (house mouse) ]

Gene ID: 66096, updated on 27-Nov-2024

Summary

Official Symbol
Lamtor4provided by MGI
Official Full Name
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4provided by MGI
Primary source
MGI:MGI:1913346
See related
Ensembl:ENSMUSG00000050552 AllianceGenome:MGI:1913346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0910001L09Rik
Summary
Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Predicted to be involved in several processes, including cellular response to amino acid stimulus; positive regulation of TORC1 signaling; and protein localization to lysosome. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of FNIP-folliculin RagC/D GAP and Ragulator complex. Predicted to be active in lysosomal membrane. Is expressed in brain and retina layer. Orthologous to human LAMTOR4 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 118.3), genital fat pad adult (RPKM 111.8) and 28 other tissues See more
Orthologs
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Genomic context

See Lamtor4 in Genome Data Viewer
Location:
5 G2; 5 77.0 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138253744..138257657)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138255482..138259395)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 454 Neighboring gene neurexophilin and PC-esterase domain family, member 5 Neighboring gene predicted gene, 22956 Neighboring gene STARR-positive B cell enhancer ABC_E532 Neighboring gene RIKEN cDNA 6330418K02 gene Neighboring gene STARR-positive B cell enhancer ABC_E4800 Neighboring gene trafficking protein particle complex 14 Neighboring gene galactose-3-O-sulfotransferase 4 Neighboring gene STAG3 cohesin complex component

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to molecular adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in TORC1 signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to amino acid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to lysosome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell size ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of FNIP-folliculin RagC/D GAP IEA
Inferred from Electronic Annotation
more info
 
part_of FNIP-folliculin RagC/D GAP ISO
Inferred from Sequence Orthology
more info
 
part_of Ragulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Ragulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of Ragulator complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lysosomal membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ragulator complex protein LAMTOR4
Names
UPF0539 protein C7orf59 homolog
late endosomal/lysosomal adaptor and MAPK and MTOR activator 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081108.2NP_001074577.1  ragulator complex protein LAMTOR4

    See identical proteins and their annotated locations for NP_001074577.1

    Status: VALIDATED

    Source sequence(s)
    BC056178, BC144958
    Consensus CDS
    CCDS39342.1
    UniProtKB/Swiss-Prot
    B7ZN18, Q8CEW4, Q8CF66, Q8CF77
    Related
    ENSMUSP00000056693.7, ENSMUST00000062067.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    138253744..138257657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)