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Eif3f eukaryotic translation initiation factor 3, subunit F [ Mus musculus (house mouse) ]

Gene ID: 66085, updated on 21-Apr-2024

Summary

Official Symbol
Eif3fprovided by MGI
Official Full Name
eukaryotic translation initiation factor 3, subunit Fprovided by MGI
Primary source
MGI:MGI:1913335
See related
Ensembl:ENSMUSG00000031029 AllianceGenome:MGI:1913335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eif3s5; 0610037M02Rik
Summary
Enables thiol-dependent deubiquitinase and translation initiation factor binding activity. Contributes to translation initiation factor activity. Involved in protein deubiquitination and translational initiation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human EIF3F (eukaryotic translation initiation factor 3 subunit F). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 509.7), stomach adult (RPKM 285.6) and 28 other tissues See more
Orthologs
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Genomic context

Location:
7 E3; 7 57.21 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (108533622..108541149)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (108934415..108941942)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily A member 3N Neighboring gene NLR family, pyrin domain containing 10 Neighboring gene STARR-positive B cell enhancer ABC_E703 Neighboring gene predicted gene, 39067 Neighboring gene predicted gene, 32309

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC90606

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal-dependent deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
enables translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation initiation factor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in IRES-dependent viral translational initiation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit F
Names
deubiquitinating enzyme eIF3f
eIF-3-epsilon
eIF3 p47
eukaryotic translation initiation factor 3, subunit 5 (epsilon)
NP_079620.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025344.2NP_079620.2  eukaryotic translation initiation factor 3 subunit F

    See identical proteins and their annotated locations for NP_079620.2

    Status: VALIDATED

    Source sequence(s)
    AK136797, AK152037, BC083190
    Consensus CDS
    CCDS21731.1
    UniProtKB/Swiss-Prot
    Q5XJV3, Q9DCH4
    UniProtKB/TrEMBL
    Q3U8X1, Q3UVY8, Q6IRT4
    Related
    ENSMUSP00000033342.7, ENSMUST00000033342.7
    Conserved Domains (1) summary
    cd08064
    Location:96358
    MPN_eIF3f; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF3f

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    108533622..108541149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)