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Tsen34 tRNA splicing endonuclease subunit 34 [ Mus musculus (house mouse) ]

Gene ID: 66078, updated on 26-Sep-2022

Summary

Official Symbol
Tsen34provided by MGI
Official Full Name
tRNA splicing endonuclease subunit 34provided by MGI
Primary source
MGI:MGI:1913328
See related
Ensembl:ENSMUSG00000035585 AllianceGenome:MGI:1913328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Leng5; 0610027F08Rik
Summary
Predicted to enable tRNA-intron endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to act upstream of or within mRNA processing and tRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2C. Orthologous to human TSEN34 (tRNA splicing endonuclease subunit 34). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 57.5), ovary adult (RPKM 44.9) and 28 other tissues See more
Orthologs
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Genomic context

See Tsen34 in Genome Data Viewer
Location:
7; 7 A1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3696086..3704034)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3693087..3701035)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex, subunit 3 Neighboring gene microRNA 3572 Neighboring gene leukocyte receptor cluster (LRC) member 1 Neighboring gene transmembrane channel-like gene family 4 Neighboring gene membrane bound O-acyltransferase domain containing 7 Neighboring gene ribosomal protein S9 Neighboring gene paired Ig-like receptor B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables tRNA-intron endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA splicing, via endonucleolytic cleavage and ligation IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA-type intron splice site recognition and cleavage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of tRNA-intron endonuclease complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tRNA-splicing endonuclease subunit Sen34
Names
leukocyte receptor cluster (LRC) member 5
leukocyte receptor cluster member 5 homolog
tRNA splicing endonuclease 34 homolog
tRNA-intron endonuclease Sen34
NP_001157676.1
NP_001157677.1
NP_077130.1
XP_006540343.2
XP_017167711.2
XP_017167712.1
XP_017167713.1
XP_017167714.1
XP_017167715.1
XP_036009227.1
XP_036009228.1
XP_036009229.1
XP_036009230.1
XP_036009231.1
XP_036009232.1
XP_036009233.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164204.1NP_001157676.1  tRNA-splicing endonuclease subunit Sen34 isoform a

    See identical proteins and their annotated locations for NP_001157676.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC171680
    Consensus CDS
    CCDS20725.1
    UniProtKB/Swiss-Prot
    Q8BMZ5, Q9CYW1
    Related
    ENSMUSP00000104270.2, ENSMUST00000108630.8
    Conserved Domains (2) summary
    pfam03985
    Location:98170
    Paf1
    pfam01974
    Location:223307
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
  2. NM_001164205.1NP_001157677.1  tRNA-splicing endonuclease subunit Sen34 isoform b

    See identical proteins and their annotated locations for NP_001157677.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment near the C-terminus, compared to isoform a.
    Source sequence(s)
    AC171680, AK003757, AK010759, CJ185990
    Consensus CDS
    CCDS51966.1
    UniProtKB/Swiss-Prot
    Q8BMZ5
    UniProtKB/TrEMBL
    Q9CWG3
    Related
    ENSMUSP00000104269.2, ENSMUST00000108629.8
    Conserved Domains (1) summary
    pfam01974
    Location:223278
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
  3. NM_024168.2NP_077130.1  tRNA-splicing endonuclease subunit Sen34 isoform a

    See identical proteins and their annotated locations for NP_077130.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents of an alternate promoter and 5' UTR, compared to variant 1, and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AK010759, AK053916, BB852464
    Consensus CDS
    CCDS20725.1
    UniProtKB/Swiss-Prot
    Q8BMZ5, Q9CYW1
    UniProtKB/TrEMBL
    Q9CWG3
    Related
    ENSMUSP00000104267.4, ENSMUST00000108627.4
    Conserved Domains (2) summary
    pfam03985
    Location:98170
    Paf1
    pfam01974
    Location:223307
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3696086..3704034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312223.2XP_017167712.1  tRNA-splicing endonuclease subunit Sen34 isoform X5

    UniProtKB/Swiss-Prot
    Q8BMZ5, Q9CYW1
    Conserved Domains (2) summary
    pfam03985
    Location:98170
    Paf1
    pfam01974
    Location:223307
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
  2. XM_017312222.3XP_017167711.2  tRNA-splicing endonuclease subunit Sen34 isoform X4

    Conserved Domains (1) summary
    pfam01974
    Location:264348
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
  3. XM_017312224.3XP_017167713.1  tRNA-splicing endonuclease subunit Sen34 isoform X5

    UniProtKB/Swiss-Prot
    Q8BMZ5, Q9CYW1
    Conserved Domains (2) summary
    pfam03985
    Location:98170
    Paf1
    pfam01974
    Location:223307
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
  4. XM_036153335.1XP_036009228.1  tRNA-splicing endonuclease subunit Sen34 isoform X3

    Conserved Domains (1) summary
    cd22363
    Location:224256
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase
  5. XM_036153338.1XP_036009231.1  tRNA-splicing endonuclease subunit Sen34 isoform X3

    Conserved Domains (1) summary
    cd22363
    Location:224256
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase
  6. XM_036153336.1XP_036009229.1  tRNA-splicing endonuclease subunit Sen34 isoform X3

    Related
    ENSMUSP00000145965.2, ENSMUST00000205287.2
    Conserved Domains (1) summary
    cd22363
    Location:224256
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase
  7. XM_036153337.1XP_036009230.1  tRNA-splicing endonuclease subunit Sen34 isoform X3

    Conserved Domains (1) summary
    cd22363
    Location:224256
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase
  8. XM_006540280.5XP_006540343.2  tRNA-splicing endonuclease subunit Sen34 isoform X2

    Conserved Domains (1) summary
    pfam01974
    Location:247331
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
  9. XM_017312225.3XP_017167714.1  tRNA-splicing endonuclease subunit Sen34 isoform X5

    UniProtKB/Swiss-Prot
    Q8BMZ5, Q9CYW1
    Conserved Domains (2) summary
    pfam03985
    Location:98170
    Paf1
    pfam01974
    Location:223307
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
  10. XM_017312226.3XP_017167715.1  tRNA-splicing endonuclease subunit Sen34 isoform X5

    UniProtKB/Swiss-Prot
    Q8BMZ5, Q9CYW1
    Conserved Domains (2) summary
    pfam03985
    Location:98170
    Paf1
    pfam01974
    Location:223307
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
  11. XM_036153334.1XP_036009227.1  tRNA-splicing endonuclease subunit Sen34 isoform X1

    Conserved Domains (1) summary
    cd22363
    Location:248280
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase
  12. XM_036153340.1XP_036009233.1  tRNA-splicing endonuclease subunit Sen34 isoform X3

    Conserved Domains (1) summary
    cd22363
    Location:224256
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase
  13. XM_036153339.1XP_036009232.1  tRNA-splicing endonuclease subunit Sen34 isoform X3

    Conserved Domains (1) summary
    cd22363
    Location:224256
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

RNA

  1. XR_003946538.2 RNA Sequence

  2. XR_003946537.1 RNA Sequence

  3. XR_003946540.2 RNA Sequence

  4. XR_003946539.2 RNA Sequence

  5. XR_001777993.2 RNA Sequence