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Txndc12 thioredoxin domain containing 12 (endoplasmic reticulum) [ Mus musculus (house mouse) ]

Gene ID: 66073, updated on 5-Mar-2024

Summary

Official Symbol
Txndc12provided by MGI
Official Full Name
thioredoxin domain containing 12 (endoplasmic reticulum)provided by MGI
Primary source
MGI:MGI:1913323
See related
Ensembl:ENSMUSG00000028567 AllianceGenome:MGI:1913323
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ERp16; ERp19; 0610040B21Rik
Summary
Predicted to enable protein-disulfide reductase activity. Predicted to be involved in negative regulation of cell death. Predicted to act upstream of or within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cranium; eye; and respiratory system. Orthologous to human TXNDC12 (thioredoxin domain containing 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 28.4), limb E14.5 (RPKM 22.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
4 C7; 4 50.64 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108691875..108719317)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (108834678..108862120)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zinc finger, FYVE domain containing 9 Neighboring gene predicted gene, 53266 Neighboring gene STARR-seq mESC enhancer starr_11051 Neighboring gene STARR-seq mESC enhancer starr_11052 Neighboring gene STARR-positive B cell enhancer mm9_chr4:108520274-108520575 Neighboring gene basic transcription factor 3-like 4 Neighboring gene KTI12 homolog, chromatin associated Neighboring gene RAB3B, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_11058 Neighboring gene RIKEN cDNA 8030443G20 gene Neighboring gene STARR-seq mESC enhancer starr_11059 Neighboring gene STARR-positive B cell enhancer ABC_E520 Neighboring gene STARR-seq mESC enhancer starr_11060 Neighboring gene nardilysin convertase Neighboring gene microRNA 761

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
thioredoxin domain-containing protein 12
Names
ER protein 19
endoplasmic reticulum protein ERp19
endoplasmic reticulum resident protein 19
ortholog of endoplasmic reticulum thioredoxin superfamily member, 18 kDa TLP19
thioredoxin-like protein p19
NP_079610.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025334.3NP_079610.1  thioredoxin domain-containing protein 12 precursor

    See identical proteins and their annotated locations for NP_079610.1

    Status: PROVISIONAL

    Source sequence(s)
    AL607070
    Consensus CDS
    CCDS18457.1
    UniProtKB/Swiss-Prot
    Q53YN1, Q9CQU0
    Related
    ENSMUSP00000030296.9, ENSMUST00000030296.9
    Conserved Domains (1) summary
    cd02959
    Location:34150
    ERp19; Endoplasmic reticulum protein 19 (ERp19) family; ERp19 is also known as ERp18, a protein located in the ER containing one redox active TRX domain. Denaturation studies indicate that the reduced form is more stable than the oxidized form, suggesting that ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    108691875..108719317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)