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Sdhaf2 succinate dehydrogenase complex assembly factor 2 [ Mus musculus (house mouse) ]

Gene ID: 66072, updated on 30-Apr-2024

Summary

Official Symbol
Sdhaf2provided by MGI
Official Full Name
succinate dehydrogenase complex assembly factor 2provided by MGI
Primary source
MGI:MGI:1913322
See related
Ensembl:ENSMUSG00000024668 AllianceGenome:MGI:1913322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610038F07Rik
Summary
Acts upstream of or within negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein dephosphorylation. Located in mitochondrion. Is expressed in several structures, including early conceptus and oocyte. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SDHAF2 (succinate dehydrogenase complex assembly factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 9.2), bladder adult (RPKM 9.1) and 28 other tissues See more
Orthologs
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Genomic context

See Sdhaf2 in Genome Data Viewer
Location:
19 A; 19 6.6 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10477876..10502573, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10500512..10525209, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 10B Neighboring gene stabilizer of axonemal microtubules 4 Neighboring gene cleavage and polyadenylation specific factor 7 Neighboring gene transmembrane protein 216 Neighboring gene transmembrane protein 138 Neighboring gene cytochrome b561 family, member A3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC61338

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial electron transport, succinate to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial electron transport, succinate to ubiquinone ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial respiratory chain complex II assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-FAD linkage IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein-FAD linkage ISO
Inferred from Sequence Orthology
more info
 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
succinate dehydrogenase assembly factor 2, mitochondrial
Names
SDH assembly factor 2
succinate dehydrogenase subunit 5, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025333.4NP_079609.2  succinate dehydrogenase assembly factor 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_079609.2

    Status: VALIDATED

    Source sequence(s)
    AC124169, AC125093, AK160957, AK167228, BP771596
    Consensus CDS
    CCDS29578.1
    UniProtKB/Swiss-Prot
    Q3TVE5, Q6PAS5, Q80ZJ9, Q8C6I2, Q8K2W8, Q9CYQ2
    UniProtKB/TrEMBL
    A0A494B9B9
    Related
    ENSMUSP00000025570.7, ENSMUST00000025570.8
    Conserved Domains (1) summary
    pfam03937
    Location:65138
    Sdh5; Flavinator of succinate dehydrogenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10477876..10502573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)